Literature DB >> 31993833

Positive and negative feedback mechanisms controlling tip/stalk cell identity during sprouting angiogenesis.

Coert Margadant1.   

Abstract

Vascular endothelial growth factor-A (VEGF-A/VEGF) interaction with VEGF receptor 2 (VEGFR2) is key for sprouting angiogenesis in health and disease. VEGF/VEGFR2 signaling promotes endothelial proliferation and migration, as well as the hierarchical organization into leader (tip) and follower (stalk) cells via a dynamic interplay with Notch. Recent studies reveal novel molecular mechanisms to fine-tune VEGF/Notch signaling and tip/stalk cell function during sprouting angiogenesis.

Entities:  

Keywords:  Dll4; ERK; Notch; Sprouting angiogenesis; Tip cells; VEGF signaling

Mesh：

Substances：

Year:  2020        PMID： 31993833     DOI： 10.1007/s10456-020-09706-0

Source DB:  PubMed          Journal:  Angiogenesis        ISSN： 0969-6970            Impact factor:   9.596


  8 in total

1.  Targeting circular RNA-MET for anti-angiogenesis treatment via inhibiting endothelial tip cell specialization.

Authors:  Mu-Di Yao; Qin Jiang; Yan Ma; Yan Zhu; Qiu-Yang Zhang; Ze-Hui Shi; Chen Zhao; Biao Yan
Journal:  Mol Ther       Date:  2022-01-07       Impact factor: 11.454

Review 2.  Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance.

Authors:  Danan Sun; Jin Wang; Sam Toan; David Muid; Ruibing Li; Xing Chang; Hao Zhou
Journal:  Angiogenesis       Date:  2022-03-18       Impact factor: 10.658

Review 3.  Infantile hepatic hemangiomas: looking backwards and forwards.

Authors:  Xue Gong; Yanan Li; Kaiying Yang; Siyuan Chen; Yi Ji
Journal:  Precis Clin Med       Date:  2022-02-11

4.  Gatekeeping role of Nf2/Merlin in vascular tip EC induction through suppression of VEGFR2 internalization.

Authors:  Jung Hyun Bae; Myung Jin Yang; Seung-Hwan Jeong; JungMo Kim; Seon Pyo Hong; Jin Woo Kim; Yoo Hyung Kim; Gou Young Koh
Journal:  Sci Adv       Date:  2022-06-10       Impact factor: 14.957

5.  Melatonin Attenuates Cardiac Ischemia-Reperfusion Injury through Modulation of IP3R-Mediated Mitochondria-ER Contact.

Authors:  Wenya Li; Botao Liu; Lin Wang; Jilie Liu; Xiuhui Yang; Jia Zheng
Journal:  Oxid Med Cell Longev       Date:  2021-08-06       Impact factor: 6.543

6.  The role of calcium oscillations in the phenotype selection in endothelial cells.

Authors:  Birses Debir; Cameron Meaney; Mohammad Kohandel; M Burcin Unlu
Journal:  Sci Rep       Date:  2021-12-10       Impact factor: 4.379

7.  BTK Promotes Atherosclerosis by Regulating Oxidative Stress, Mitochondrial Injury, and ER Stress of Macrophages.

Authors:  Junxiong Qiu; Yuan Fu; Zhiteng Chen; Lisui Zhang; Ling Li; Diefei Liang; Feng Wei; Zhuzhi Wen; Yajing Wang; Shi Liang
Journal:  Oxid Med Cell Longev       Date:  2021-05-27       Impact factor: 6.543

Review 8.  Molecular Perspectives of Mitophagy in Myocardial Stress: Pathophysiology and Therapeutic Targets.

Authors:  Haizhe Ji; Dan Wu; O'Maley Kimberlee; Ruibing Li; Geng Qian
Journal:  Front Physiol       Date:  2021-06-30       Impact factor: 4.755
  8 in total

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