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Literature DB >> 31993503

Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis.

Abstract

Ferroptosis is a novel form of programmed cell death. We found that the ferroptosis sensitivity in renal and ovarian cancers are regulated by cell density through TAZ-EMP1-NOX4 and TAZ-ANGPTL4-NOX2 pathway, respectively. These findings reveal TAZ as a novel genetic determinant of ferroptosis. Triggering ferroptosis may have therapeutic potential for TAZ-activated tumors.

Entities: Disease Gene

Keywords: Angiopoietin-Like 4 (ANGPTL4); Epithelial Membrane Protein 1 (EMP1); Erastin; Ferroptosis; Hippo pathway; NADPH Oxidase 2 (NOX2); NADPH Oxidase 4 (NOX4); Ovarian Cancer; Renal Cell Carcinoma; Yes-associated protein 1 (YAP1); transcriptional coactivator with PDZ-binding motif (TAZ)

Year: 2019 PMID： 31993503 PMCID： PMC6961671 DOI： 10.1080/23723556.2019.1699375

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

6 in total

1. The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma.

Authors: Wen-Hsuan Yang; Chien-Kuang Cornelia Ding; Tianai Sun; Gabrielle Rupprecht; Chao-Chieh Lin; David Hsu; Jen-Tsan Chi
Journal: Cell Rep Date: 2019-09-03 Impact factor: 9.423

Review 2. Ferroptosis: process and function.

Authors: Y Xie; W Hou; X Song; Y Yu; J Huang; X Sun; R Kang; D Tang
Journal: Cell Death Differ Date: 2016-01-22 Impact factor: 15.828

3. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.

Authors: Vasanthi S Viswanathan; Matthew J Ryan; Harshil D Dhruv; Shubhroz Gill; Ossia M Eichhoff; Brinton Seashore-Ludlow; Samuel D Kaffenberger; John K Eaton; Kenichi Shimada; Andrew J Aguirre; Srinivas R Viswanathan; Shrikanta Chattopadhyay; Pablo Tamayo; Wan Seok Yang; Matthew G Rees; Sixun Chen; Zarko V Boskovic; Sarah Javaid; Cherrie Huang; Xiaoyun Wu; Yuen-Yi Tseng; Elisabeth M Roider; Dong Gao; James M Cleary; Brian M Wolpin; Jill P Mesirov; Daniel A Haber; Jeffrey A Engelman; Jesse S Boehm; Joanne D Kotz; Cindy S Hon; Yu Chen; William C Hahn; Mitchell P Levesque; John G Doench; Michael E Berens; Alykhan F Shamji; Paul A Clemons; Brent R Stockwell; Stuart L Schreiber
Journal: Nature Date: 2017-07-05 Impact factor: 49.962

Review 4. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Authors: Brent R Stockwell; José Pedro Friedmann Angeli; Hülya Bayir; Ashley I Bush; Marcus Conrad; Scott J Dixon; Simone Fulda; Sergio Gascón; Stavroula K Hatzios; Valerian E Kagan; Kay Noel; Xuejun Jiang; Andreas Linkermann; Maureen E Murphy; Michael Overholtzer; Atsushi Oyagi; Gabriela C Pagnussat; Jason Park; Qitao Ran; Craig S Rosenfeld; Konstantin Salnikow; Daolin Tang; Frank M Torti; Suzy V Torti; Shinya Toyokuni; K A Woerpel; Donna D Zhang
Journal: Cell Date: 2017-10-05 Impact factor: 41.582

Review 5. YAP/TAZ at the Roots of Cancer.

Authors: Francesca Zanconato; Michelangelo Cordenonsi; Stefano Piccolo
Journal: Cancer Cell Date: 2016-06-13 Impact factor: 31.743

6. Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth.

Authors: Shira L Cramer; Achinto Saha; Jinyun Liu; Surendar Tadi; Stefano Tiziani; Wupeng Yan; Kendra Triplett; Candice Lamb; Susan E Alters; Scott Rowlinson; Yan Jessie Zhang; Michael J Keating; Peng Huang; John DiGiovanni; George Georgiou; Everett Stone
Journal: Nat Med Date: 2016-11-21 Impact factor: 53.440

6 in total

18 in total

1. SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway.

Authors: Kun Fang; Sha Du; Dachuan Shen; Zhipeng Xiong; Ke Jiang; Dapeng Liang; Jianxin Wang; Huizhe Xu; Lulu Hu; Xingyue Zhai; Yuting Jiang; Zhiyu Xia; Chunrui Xie; Di Jin; Wei Cheng; Songshu Meng; Yifei Wang
Journal: iScience Date: 2022-06-16

2. The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells.

Authors: Tanu Singh; Alexander Beatty; Jeffrey R Peterson
Journal: Cell Death Discov Date: 2022-05-06

Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis.

1. The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma.

Review 2. Ferroptosis: process and function.

3. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.

Review 4. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Review 5. YAP/TAZ at the Roots of Cancer.

6. Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth.

1. SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway.

2. The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells.

3. The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2.

4. Identification and initial characterization of a potent inhibitor of ferroptosis.

Review 5. The Intersection of DNA Damage Response and Ferroptosis-A Rationale for Combination Therapeutics.

Review 6. Roles of ferroptosis in urologic malignancies.

7. Identification and validation of a ferroptosis-related gene signature predictive of prognosis in breast cancer.

Review 8. Fatty Acids Metabolism: The Bridge Between Ferroptosis and Ionizing Radiation.

Review 9. Emerging mechanisms and targeted therapy of ferroptosis in cancer.

Review 10. Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis.