Zhanlin Zhao1,2, Yu Yue1,2, Siyi Zhang1,2, Jiaying Zhang1,2, Xiangyang Zhu3, Vittoria Aragno4,5, Antoine Labbe4,5, Xianqun Fan6,7, Fu Yao8,9. 1. Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. 2. Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. 3. Institute of Image Communication and Network Engineering, Shanghai Jiao Tong University, Shanghai, China. 4. Department of Ophthalmology, Ambroise Paré Hospital, APHP, University of Paris Saclay, Paris, France. 5. Department of Ophthalmology III, Quinze-Vingts Hospital, Paris, France. 6. Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. fanxq@sjtu.edu.cn. 7. Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. fanxq@sjtu.edu.cn. 8. Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. drfuyaofy@sina.com. 9. Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. drfuyaofy@sina.com.
Abstract
PURPOSE: To demonstrate the marginal corneal vascular remodelling using optical coherence tomography angiography (OCTA) after pterygium surgery. METHODS: Twenty-two eyes of 19 patients (8 males, 11 females; age, 58.68 ± 0.34 years) with primary grade-T3 nasal pterygium were enroled in this study. The eyes underwent excision of the pterygium followed by a free limbal-conjunctival autograft. OCTA was performed in the nasal limbal area before surgery and at 10 days, 1 month, and 3 months after surgery. The scans were analyzed in terms of postoperative vascular remodelling of the autograft and marginal corneal vascular arcades (MCAs). RESULTS: Preoperatively, the pterygium presented as abnormal centripetal vascular growth in OCTA scans. The conjunctival vessel density in the nasal quadrant was 29.26% ± 1.00%, 15.80% ± 0.83%, 19.80% ± 0.88%, and 20.26% ± 0.89% before and 10 days, 1 month, and 3 months, respectively, after surgery (F = 1.55, P < 0.01). The vessel density of MCAs was 28.33% ± 0.88%, 42.09% ± 0.41%, and 42.46% ± 0.31% 10 days, 1 month, and 3 months, respectively, after surgery (F = 188.2, P < 0.01). CONCLUSIONS: We describe a new application of OCTA for MCA vasculature imaging. Vascular remodelling of the graft and MCAs appeared at 1 month and continued for 3 months after surgery.
PURPOSE: To demonstrate the marginal corneal vascular remodelling using optical coherence tomography angiography (OCTA) after pterygium surgery. METHODS: Twenty-two eyes of 19 patients (8 males, 11 females; age, 58.68 ± 0.34 years) with primary grade-T3 nasal pterygium were enroled in this study. The eyes underwent excision of the pterygium followed by a free limbal-conjunctival autograft. OCTA was performed in the nasal limbal area before surgery and at 10 days, 1 month, and 3 months after surgery. The scans were analyzed in terms of postoperative vascular remodelling of the autograft and marginal corneal vascular arcades (MCAs). RESULTS: Preoperatively, the pterygium presented as abnormal centripetal vascular growth in OCTA scans. The conjunctival vessel density in the nasal quadrant was 29.26% ± 1.00%, 15.80% ± 0.83%, 19.80% ± 0.88%, and 20.26% ± 0.89% before and 10 days, 1 month, and 3 months, respectively, after surgery (F = 1.55, P < 0.01). The vessel density of MCAs was 28.33% ± 0.88%, 42.09% ± 0.41%, and 42.46% ± 0.31% 10 days, 1 month, and 3 months, respectively, after surgery (F = 188.2, P < 0.01). CONCLUSIONS: We describe a new application of OCTA for MCA vasculature imaging. Vascular remodelling of the graft and MCAs appeared at 1 month and continued for 3 months after surgery.
Authors: Jonathan Luisi; Edward R Kraft; Steven A Giannos; Krishna Patel; Mary E Schmitz-Brown; Valentina Reffatto; Kevin H Merkley; Praveena K Gupta Journal: Transl Vis Sci Technol Date: 2021-03-01 Impact factor: 3.283