| Literature DB >> 3199074 |
J P Coutelier1, J T van der Logt, F W Heessen, A Vink, J van Snick.
Abstract
The isotypic distribution of murine IgG was examined after infection with several viruses. The results indicate that when a hypergammaglobulinemia was induced by the infection, it was restricted to the IgG2a and, to a lesser extent, to the IgG2b subclasses. In addition, when mice were infected with some viruses concomitantly with the immunization with a soluble protein antigen, a modification in the isotypic distribution of antiprotein antibodies was observed, with a preferential production of IgG2a. These observations indicate that viral infections can actively influence the switch of Igs and selectively stimulate the production of the IgG2a subclass.Entities:
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Year: 1988 PMID： 3199074 PMCID： PMC2189165 DOI： 10.1084/jem.168.6.2373
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307