| Literature DB >> 31988379 |
Elena Zagato1,2, Chiara Pozzi3, Alice Bertocchi3, Tiziana Schioppa4, Fabiana Saccheri1, Silvia Guglietta1,5, Bruno Fosso6, Laura Melocchi7,8, Giulia Nizzoli9, Jacopo Troisi10,11,12, Marinella Marzano6, Bianca Oresta3, Ilaria Spadoni13, Koji Atarashi14,15, Sara Carloni13, Stefania Arioli16, Giulia Fornasa3, Francesco Asnicar17, Nicola Segata17, Simone Guglielmetti16, Kenya Honda14,15, Graziano Pesole6,18, William Vermi7,19, Giuseppe Penna3, Maria Rescigno20,21.
Abstract
The microbiota has been shown to promote intestinal tumourigenesis, but a possible anti-tumourigenic effect has also been postulated. Here, we demonstrate that changes in the microbiota and mucus composition are concomitant with tumourigenesis. We identified two anti-tumourigenic strains of the microbiota-Faecalibaculum rodentium and its human homologue, Holdemanella biformis-that are strongly under-represented during tumourigenesis. Reconstitution of ApcMin/+ or azoxymethane- and dextran sulfate sodium-treated mice with an isolate of F. rodentium (F. PB1) or its metabolic products reduced tumour growth. Both F. PB1 and H. biformis produced short-chain fatty acids that contributed to control protein acetylation and tumour cell proliferation by inhibiting calcineurin and NFATc3 activation in mouse and human settings. We have thus identified endogenous anti-tumourigenic bacterial strains with strong diagnostic, therapeutic and translational potential.Entities:
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Year: 2020 PMID： 31988379 PMCID： PMC7048616 DOI： 10.1038/s41564-019-0649-5
Source DB: PubMed Journal: Nat Microbiol ISSN： 2058-5276 Impact factor: 17.745