Z S Ulhaq1. 1. Department of Biomedical Science, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim Islamic State University of Malang, East Java, Indonesia. Electronic address: zulhaq@kedokteran.uin-malang.ac.id.
Abstract
OBJECTIVE: To estimate an accurate level of IL-8 in aqueous humor among open-angle glaucoma (OAG) patients. METHODS: Meta-analysis was performed from available studies that investigated the IL-8 level in the aqueous humor of OAG patients and control subjects. RESULTS: A total of 17 studies were selected. The pooled result showed that IL-8 levels in aqueous humor of patients with OAG were higher than in control subjects (SMD=0.98, 95% CI=0.68-1.27, p<0.00001). CONCLUSION: This meta-analysis indicates that patients with OAG may have a higher aqueous humor IL-8 levels compared to control subjects, which supports the notion that IL-8 is one of the contributing factors in the development of OAG.
OBJECTIVE: To estimate an accurate level of IL-8 in aqueous humor among open-angle glaucoma (OAG) patients. METHODS: Meta-analysis was performed from available studies that investigated the IL-8 level in the aqueous humor of OAGpatients and control subjects. RESULTS: A total of 17 studies were selected. The pooled result showed that IL-8 levels in aqueous humor of patients with OAG were higher than in control subjects (SMD=0.98, 95% CI=0.68-1.27, p<0.00001). CONCLUSION: This meta-analysis indicates that patients with OAG may have a higher aqueous humor IL-8 levels compared to control subjects, which supports the notion that IL-8 is one of the contributing factors in the development of OAG.