Junhong Chen1, Weicong Pan2, Yongjin Chen2, Lijia Wen2, Jihao Tu1, Kai Liu3. 1. College of Clinical Medicine, Jilin University, Changchun, China. 2. Department of Hepatopancreatobiliary Surgery, The First Hospital, Jilin University, Changchun, China. 3. Department of Hepatopancreatobiliary Surgery, The First Hospital, Jilin University, Changchun, China. kailiu95@yahoo.com.
Abstract
BACKGROUND: Aldehyde dehydrogenase 2 (ALDH2) and cytochrome p450 2E1 (CYP2E1) are important alcohol-metabolizing enzymes. The aim of this meta-analysis was to evaluate the association of ALDH2 rs671 and CYP2E1 rs2031920 polymorphisms with hepatocellular carcinoma (HCC) susceptibility in East Asians. METHODS: A systematic search strategy was implemented in MEDLINE, PubMed, Scopus, Embase, and China Academic Journals databases. Nineteen case-control studies were selected for inclusion. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated through random-effects or fixed-effects models. Subgroup analysis, meta-regression, sensitivity analysis, cumulative meta-analysis, and evaluation of publication bias were performed. RESULTS: The overall meta-analysis did not find a significant association of ALDH2 rs671 and CYP2E1 rs2031920 genotypes with HCC susceptibility in East Asians. In addition, stratified analysis by country, Hardy-Weinberg equilibrium status, and source of controls also did not identify any association. CONCLUSION: The ALDH2 rs671 and CYP2E1 rs2031920 polymorphisms are not associated with HCC susceptibility in East Asians.
BACKGROUND:Aldehyde dehydrogenase 2 (ALDH2) and cytochrome p450 2E1 (CYP2E1) are important alcohol-metabolizing enzymes. The aim of this meta-analysis was to evaluate the association of ALDH2rs671 and CYP2E1rs2031920 polymorphisms with hepatocellular carcinoma (HCC) susceptibility in East Asians. METHODS: A systematic search strategy was implemented in MEDLINE, PubMed, Scopus, Embase, and China Academic Journals databases. Nineteen case-control studies were selected for inclusion. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated through random-effects or fixed-effects models. Subgroup analysis, meta-regression, sensitivity analysis, cumulative meta-analysis, and evaluation of publication bias were performed. RESULTS: The overall meta-analysis did not find a significant association of ALDH2rs671 and CYP2E1rs2031920 genotypes with HCC susceptibility in East Asians. In addition, stratified analysis by country, Hardy-Weinberg equilibrium status, and source of controls also did not identify any association. CONCLUSION: The ALDH2rs671 and CYP2E1rs2031920 polymorphisms are not associated with HCC susceptibility in East Asians.
Authors: Pek Kei Im; Ling Yang; Christiana Kartsonaki; Yiping Chen; Yu Guo; Huaidong Du; Kuang Lin; Rene Kerosi; Alex Hacker; Jingchao Liu; Canqing Yu; Jun Lv; Robin G Walters; Liming Li; Zhengming Chen; Iona Y Millwood Journal: Int J Cancer Date: 2022-01-20 Impact factor: 7.316