| Literature DB >> 3198495 |
T Yoshioka1, K Kiyoshima, M Maeda, M Sakamoto, T Ishikura, Y Fukagawa, T Sawa, M Hamada, H Naganawa, T Takeuchi.
Abstract
Eleven 4''-O-acyltylosin derivatives were synthesized and subjected to a two-step screening system consisting of antimicrobial activity and esterase stability assays. The new derivatives were all active against macrolide-resistant Staphylococci and mycoplasmas, but only 4''-O-(4-methoxy)phenylacetyltylosin and 4''-O-(4-acetyl)phenylacetyltylosin showed better resistance to mouse liver esterase than 4''-O-phenylacetyltylosin (reference compound C).Entities:
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Year: 1988 PMID： 3198495 DOI： 10.7164/antibiotics.41.1617
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649