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Literature DB >> 31983353

New imaging tools to measure nephron number in vivo: opportunities for developmental nephrology.

K M Bennett¹, E J Baldelomar¹, D Morozov¹, R L Chevalier², J R Charlton².

Abstract

The mammalian kidney is a complex organ, requiring the concerted function of up to millions of nephrons. The number of nephrons is constant after nephrogenesis during development, and nephron loss over a life span can lead to susceptibility to acute or chronic kidney disease. New technologies are under development to count individual nephrons in the kidney in vivo. This review outlines these technologies and highlights their relevance to studies of human renal development and disease.

Entities: Chemical

Keywords: CFE-MRI; glomerulus; imaging; kidney development; magnetic resonance imaging; nephron number

Mesh：

Year: 2020 PMID： 31983353 PMCID： PMC8765346 DOI： 10.1017/S204017442000001X

Source DB: PubMed Journal: J Dev Orig Health Dis ISSN： 2040-1744 Impact factor: 2.401

48 in total

1. A unifying view of ageing and disease: the double-agent theory.

Authors: Nick Lane
Journal: J Theor Biol Date: 2003-12-21 Impact factor: 2.691

Review 2. MRI tools for assessment of microstructure and nephron function of the kidney.

Authors: Luke Xie; Kevin M Bennett; Chunlei Liu; G Allan Johnson; Jeff Lei Zhang; Vivian S Lee
Journal: Am J Physiol Renal Physiol Date: 2016-09-14

Review 3. Human nephron number: implications for health and disease.

Authors: John F Bertram; Rebecca N Douglas-Denton; Boucar Diouf; Michael D Hughson; Wendy E Hoy
Journal: Pediatr Nephrol Date: 2011-05-22 Impact factor: 3.714

Review 4. Nephron number and its determinants in early life: a primer.

Authors: Jennifer R Charlton; Caleb H Springsteen; J Bryan Carmody
Journal: Pediatr Nephrol Date: 2014-02-01 Impact factor: 3.714

Review 5. The clinical importance of nephron mass.

Authors: Valerie A Luyckx; Barry M Brenner
Journal: J Am Soc Nephrol Date: 2010-02-11 Impact factor: 10.121

Review 6. In-vivo techniques for determining nephron number.

Authors: Aleksandar Denic; Hisham Elsherbiny; Andrew D Rule
Journal: Curr Opin Nephrol Hypertens Date: 2019-11 Impact factor: 2.894

7. A common RET variant is associated with reduced newborn kidney size and function.

Authors: Zhao Zhang; Jackie Quinlan; Wendy Hoy; Michael D Hughson; Mathieu Lemire; Thomas Hudson; Pierre-Alain Hueber; Alice Benjamin; Anne Roy; Elena Pascuet; Meigan Goodyer; Chandhana Raju; Fiona Houghton; John Bertram; Paul Goodyer
Journal: J Am Soc Nephrol Date: 2008-10 Impact factor: 10.121

8. Nephron number in patients with primary hypertension.

Authors: Gunhild Keller; Gisela Zimmer; Gerhard Mall; Eberhard Ritz; Kerstin Amann
Journal: N Engl J Med Date: 2003-01-09 Impact factor: 91.245

9. MRI-based glomerular morphology and pathology in whole human kidneys.

Authors: Scott C Beeman; Luise A Cullen-McEwen; Victor G Puelles; Min Zhang; Teresa Wu; Edwin J Baldelomar; John Dowling; Jennifer R Charlton; Michael S Forbes; Amanda Ng; Qi-zhu Wu; James A Armitage; Gary F Egan; John F Bertram; Kevin M Bennett
Journal: Am J Physiol Renal Physiol Date: 2014-03-19

10. Phenotyping by magnetic resonance imaging nondestructively measures glomerular number and volume distribution in mice with and without nephron reduction.

Authors: Edwin J Baldelomar; Jennifer R Charlton; Scott C Beeman; Bradley D Hann; Luise Cullen-McEwen; Valeria M Pearl; John F Bertram; Teresa Wu; Min Zhang; Kevin M Bennett
Journal: Kidney Int Date: 2016-02 Impact factor: 10.612

3 in total