Anne Jarstein Skjulsvik1,2, Hans Kristian Bø3,4, Asgeir Store Jakola5,6,7, Erik Magnus Berntsen4,8, Lars Eirik Bø9, Ingerid Reinertsen9, Kristin Smistad Myrmel10, Kristin Sjåvik11, Kristin Åberg10, Thomas Berg10, Hong Yan Dai12, Roar Kloster11, Sverre Helge Torp12,13, Ole Solheim14,7. 1. Department of Pathology, St. Olavs University Hospital, Trondheim, Norway. anne.j.skjulsvik@ntnu.no. 2. Departments of Clinical and Molecular Medicine, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, 7491, Trondheim, Norway. anne.j.skjulsvik@ntnu.no. 3. Department of Diagnostic Imaging, Nordland Hospital Trust, Bodø, Norway. 4. Department of Circulation and Medical Imaging, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, 7491, Trondheim, Norway. 5. Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden. 6. Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, Sweden. 7. Department of Neuroscience and Movement Medicine, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, 7491, Trondheim, Norway. 8. Department of Radiology and Nuclear Medicine, St. Olavs University Hospital, Olav Kyrres Gate, 7006, Trondheim, Norway. 9. Department of Health Research, SINTEF Digital, Trondheim, Norway. 10. Department of Clinical Pathology, University Hospital of North Norway, Tromsö, Norway. 11. Department of Neurosurgery, University Hospital of North Norway, Tromsö, Norway. 12. Department of Pathology, St. Olavs University Hospital, Trondheim, Norway. 13. Departments of Clinical and Molecular Medicine, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, 7491, Trondheim, Norway. 14. Department of Neurosurgery, St. Olavs University Hospital, Olav Kyrres Gate, 7006, Trondheim, Norway.
Abstract
INTRODUCTION: According to the stem cell theory, two neurogenic niches in the adult human brain may harbor cells that initiate the formation of gliomas: The larger subventricular zone (SVZ) and the subgranular zone (SGZ) in the hippocampus. We wanted to explore whether defining molecular markers in low-grade gliomas (LGG; WHO grade II) are related to distance to the neurogenic niches. METHODS: Patients treated at two Norwegian university hospitals with population-based referral were included. Eligible patients had histopathological verified supratentorial low-grade glioma. IDH mutational status and 1p19q co-deletion status was retrospectively assessed. 159 patients were included, and semi-automatic tumor segmentation was done from pre-treatment T2-weighted (T2W) or Fluid-Attenuated Inversion Recovery (FLAIR) images. 3D maps showing the anatomical distribution of the tumors were then created for each of the three molecular subtypes (IDH mutated/1p19q co-deleted, IDH mutated and IDH wild-type). Both distance from tumor center and tumor border to the neurogenic niches were recorded. RESULTS: In this population-based cohort of previously untreated low-grade gliomas, we found that low-grade gliomas are more often found closer to the SVZ than the SGZ, but IDH wild-type tumors are more often found near SGZ. CONCLUSION: Our study suggests that the stem cell origin of IDH wild-type and IDH mutated low-grade gliomas may be different.
INTRODUCTION: According to the stem cell theory, two neurogenic niches in the adult human brain may harbor cells that initiate the formation of gliomas: The larger subventricular zone (SVZ) and the subgranular zone (SGZ) in the hippocampus. We wanted to explore whether defining molecular markers in low-grade gliomas (LGG; WHO grade II) are related to distance to the neurogenic niches. METHODS:Patients treated at two Norwegian university hospitals with population-based referral were included. Eligible patients had histopathological verified supratentorial low-grade glioma. IDH mutational status and 1p19q co-deletion status was retrospectively assessed. 159 patients were included, and semi-automatic tumor segmentation was done from pre-treatment T2-weighted (T2W) or Fluid-Attenuated Inversion Recovery (FLAIR) images. 3D maps showing the anatomical distribution of the tumors were then created for each of the three molecular subtypes (IDH mutated/1p19q co-deleted, IDH mutated and IDH wild-type). Both distance from tumor center and tumor border to the neurogenic niches were recorded. RESULTS: In this population-based cohort of previously untreated low-grade gliomas, we found that low-grade gliomas are more often found closer to the SVZ than the SGZ, but IDH wild-type tumors are more often found near SGZ. CONCLUSION: Our study suggests that the stem cell origin of IDH wild-type and IDH mutated low-grade gliomas may be different.
Entities:
Keywords:
1p19q co-deletion; 3D brain map; IDH mutation; Low-grade glioma; Subgranular zone; Subventricular zone
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