Tadashi Umehara1,2, Hisayoshi Oka3, Atsuo Nakahara3, Tomotaka Shiraishi4, Takeo Sato4, Hiromasa Matsuno4, Teppei Komatsu4, Shusaku Omoto4, Hidetomo Murakami4, Yasuyuki Iguchi4. 1. Department of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan. tumety@jikei.ac.jp. 2. Department of Neurology, Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan. tumety@jikei.ac.jp. 3. Department of Neurology, Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan. 4. Department of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Abstract
PURPOSE: Sympathetic nervous denervation may be associated with the development of anemia. We aimed to investigate the association between sympathetic nervous denervation and hemoglobin levels in patients with Parkinson's disease (PD). METHODS: As indices of sympathetic nervous denervation, we investigated resting norepinephrine levels, increased norepinephrine levels after tilt-up, cardiac uptake of 123I-metaiodobenzylguanidine, supine blood pressure, and the degree of orthostatic hypotension in 132 patients with de novo PD. RESULTS: Older age, female sex, severe motor dysfunction, and lower body mass index were associated with decreased hemoglobin levels. After adjustment for these covariables, resting norepinephrine levels were negatively associated with hemoglobin levels. Hemoglobin levels were not associated with cardiac sympathetic denervation or orthostatic intolerance. CONCLUSION: Hemoglobin levels in PD seem to be closely related to noradrenergic nervous activity and nigrostriatal dopaminergic degeneration. In contrast to expectations, decreased hemoglobin levels were associated with increased whole-body sympathetic nervous activity in PD.
PURPOSE: Sympathetic nervous denervation may be associated with the development of anemia. We aimed to investigate the association between sympathetic nervous denervation and hemoglobin levels in patients with Parkinson's disease (PD). METHODS: As indices of sympathetic nervous denervation, we investigated resting norepinephrine levels, increased norepinephrine levels after tilt-up, cardiac uptake of 123I-metaiodobenzylguanidine, supine blood pressure, and the degree of orthostatic hypotension in 132 patients with de novo PD. RESULTS: Older age, female sex, severe motor dysfunction, and lower body mass index were associated with decreased hemoglobin levels. After adjustment for these covariables, resting norepinephrine levels were negatively associated with hemoglobin levels. Hemoglobin levels were not associated with cardiac sympathetic denervation or orthostatic intolerance. CONCLUSION: Hemoglobin levels in PD seem to be closely related to noradrenergic nervous activity and nigrostriatal dopaminergic degeneration. In contrast to expectations, decreased hemoglobin levels were associated with increased whole-body sympathetic nervous activity in PD.
Authors: Camille G Apple; Elizabeth S Miller; Kolenkode B Kannan; Chase Thompson; Dijoia B Darden; Philip A Efron; Alicia M Mohr Journal: J Surg Res Date: 2021-06-26 Impact factor: 2.192