Elizabeth E Foglia1, Erik A Jensen2, Myra H Wyckoff3, Taylor Sawyer4, Alexis Topjian5, Sarah J Ratcliffe6. 1. Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, United States. Electronic address: foglia@email.chop.edu. 2. Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, United States. 3. Division of Neonatology, Department of Pediatrics, UT Southwestern, Dallas, TX, United States. 4. Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, United States. 5. Divsion of Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States. 6. Division of Biostatistics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States.
Abstract
AIMS: Survival after delivery room cardiopulmonary resuscitation (DR-CPR) is not well characterized in full-term infants, and survival outcomes after DR-CPR have not been defined across the spectrum of gestation. The study objectives were to define gestational age (GA) specific survival following DR-CPR and to assess the association between GA and DR-CPR characteristics and survival outcomes. METHODS: Retrospective cohort study of prospectively collected data in the American Heart Association Get With the Guidelines-Resuscitation registry. Newborn infants without congenital abnormalities who received greater than 1 min of chest compressions for DR-CPR were included. GA was stratified by categorical subgroups: ≥36 weeks; 33-356/7 weeks; 29-326/7 weeks; 25-286/7 weeks; 22-246/7 weeks. The primary outcome was survival to hospital discharge; the secondary outcome was return of circulation (ROC). RESULTS: Among 1022 infants who received DR-CPR, 83% experienced ROC and 64% survived to hospital discharge. GA-stratified hospital survival rates were 83% (≥36 weeks), 66% (33-35 weeks), 60% (29-32 weeks), 52% (25-28 weeks), and 25% (22-24 weeks). Compared with GA ≥ 36 weeks, lower GA was independently associated with decreasing odds of survival (33-35 weeks: adjusted Odds Ratio [aOR] 0.46, 95% Confidence Interval [CI] 0.26-0.81; 29-32 weeks: aOR 0.40, 95% CI 0.23-0.69; 25-28 weeks: aOR 0.21, 95% CI 0.11-0.41; 22-24 weeks: aOR 0.06, 95% CI 0.03-0.10). CONCLUSIONS: In this national registry of infants who received delivery room cardiopulmonary resuscitation (DR-CPR), 83% survived the event and two-thirds survived to hospital discharge. These results contribute to defining survival outcomes following DR-CPR across the continuum of gestation.
AIMS: Survival after delivery room cardiopulmonary resuscitation (DR-CPR) is not well characterized in full-term infants, and survival outcomes after DR-CPR have not been defined across the spectrum of gestation. The study objectives were to define gestational age (GA) specific survival following DR-CPR and to assess the association between GA and DR-CPR characteristics and survival outcomes. METHODS: Retrospective cohort study of prospectively collected data in the American Heart Association Get With the Guidelines-Resuscitation registry. Newborn infants without congenital abnormalities who received greater than 1 min of chest compressions for DR-CPR were included. GA was stratified by categorical subgroups: ≥36 weeks; 33-356/7 weeks; 29-326/7 weeks; 25-286/7 weeks; 22-246/7 weeks. The primary outcome was survival to hospital discharge; the secondary outcome was return of circulation (ROC). RESULTS: Among 1022 infants who received DR-CPR, 83% experienced ROC and 64% survived to hospital discharge. GA-stratified hospital survival rates were 83% (≥36 weeks), 66% (33-35 weeks), 60% (29-32 weeks), 52% (25-28 weeks), and 25% (22-24 weeks). Compared with GA ≥ 36 weeks, lower GA was independently associated with decreasing odds of survival (33-35 weeks: adjusted Odds Ratio [aOR] 0.46, 95% Confidence Interval [CI] 0.26-0.81; 29-32 weeks: aOR 0.40, 95% CI 0.23-0.69; 25-28 weeks: aOR 0.21, 95% CI 0.11-0.41; 22-24 weeks: aOR 0.06, 95% CI 0.03-0.10). CONCLUSIONS: In this national registry of infants who received delivery room cardiopulmonary resuscitation (DR-CPR), 83% survived the event and two-thirds survived to hospital discharge. These results contribute to defining survival outcomes following DR-CPR across the continuum of gestation.
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