Olivier Leleu1, Damien Basille2, Marianne Auquier3, Caroline Clarot4, Estelle Hoguet4, Valérie Pétigny5, Amale Aït Addi2, Bernard Milleron6, Bruno Chauffert7, Pascal Berna8, Vincent Jounieaux2. 1. Department of Pulmonology, Center Hospitalier d'Abbeville, Abbeville, France. Electronic address: leleu.olivier@ch-abbeville.fr. 2. Department of Pulmonology, CHU Amiens, Amiens, France. 3. Department of Radiology, CHU Amiens, Amiens, France. 4. Department of Pulmonology, Center Hospitalier d'Abbeville, Abbeville, France. 5. ADEMA80, Amiens, France. 6. Intergroupe francophone de cancérologie thoracique (IFCT), Paris, France. 7. Department of Medical Oncology, CHU Amiens, Amiens, France. 8. Department of Thoracic Surgery, CHU Amiens, Amiens, France.
Abstract
BACKGROUND: Lung cancer mortality has been found to decrease significantly with low-dose (LD) computed tomographic (CT) screening among current or former smokers. However, such a screening program is not implemented in France. This study assessed the feasibility of a lung cancer screening program using LD CT scan in a French administrative territory. We report here the results of the first screening round. PATIENTS AND METHODS: DEP KP80 was a single-arm prospective study initiated in May 2016. Participants aged 55 to 74 years, current or former smokers of ≥ 30 pack-years, were recruited. An annual LD CT scan was scheduled. Our algorithms considered nodules < 5 mm as negative findings and nodules > 10 mm as positive; for intermediate nodules between 5 and 10 mm, 3-month CT scan with doubling time measurement was recommended. All general practitioners, pulmonologists, and radiologists from the Somme department were solicited to participate. Subjects were selected by general practitioners or pulmonologists who checked the inclusion criteria and prescribed the CT scan. RESULTS: Over a 2.5-year period, 1307 subjects were recruited. Screening was negative in 733 cases (77.2%), positive in 54 (5.7%), and indeterminate in 162 (17.1%). After the 3-month scans, 57 subjects screened positive: 26 patients exhibited 31 lung cancers (67.7% of stage 0 to I), of whom 76.9% underwent surgical resection, and 29 had no cancer (false-positive rate = 3.1%). The prevalence of lung cancer was 2.7%. CONCLUSION: This study demonstrated the feasibility of organized lung cancer screening using LD CT scan within a real-life context in the general population.
BACKGROUND:Lung cancer mortality has been found to decrease significantly with low-dose (LD) computed tomographic (CT) screening among current or former smokers. However, such a screening program is not implemented in France. This study assessed the feasibility of a lung cancer screening program using LD CT scan in a French administrative territory. We report here the results of the first screening round. PATIENTS AND METHODS: DEP KP80 was a single-arm prospective study initiated in May 2016. Participants aged 55 to 74 years, current or former smokers of ≥ 30 pack-years, were recruited. An annual LD CT scan was scheduled. Our algorithms considered nodules < 5 mm as negative findings and nodules > 10 mm as positive; for intermediate nodules between 5 and 10 mm, 3-month CT scan with doubling time measurement was recommended. All general practitioners, pulmonologists, and radiologists from the Somme department were solicited to participate. Subjects were selected by general practitioners or pulmonologists who checked the inclusion criteria and prescribed the CT scan. RESULTS: Over a 2.5-year period, 1307 subjects were recruited. Screening was negative in 733 cases (77.2%), positive in 54 (5.7%), and indeterminate in 162 (17.1%). After the 3-month scans, 57 subjects screened positive: 26 patients exhibited 31 lung cancers (67.7% of stage 0 to I), of whom 76.9% underwent surgical resection, and 29 had no cancer (false-positive rate = 3.1%). The prevalence of lung cancer was 2.7%. CONCLUSION: This study demonstrated the feasibility of organized lung cancer screening using LD CT scan within a real-life context in the general population.
Authors: Suzanne Wait; Arturo Alvarez-Rosete; Tasnime Osama; Dani Bancroft; Robin Cornelissen; Ante Marušić; Pilar Garrido; Mariusz Adamek; Jan van Meerbeeck; Annemiek Snoeckx; Olivier Leleu; Ebba Hallersjö Hult; Sébastien Couraud; David R Baldwin Journal: JTO Clin Res Rep Date: 2022-04-22
Authors: Xiushan Zheng; Bo He; Yunhai Hu; Min Ren; Zhiyuan Chen; Zhiguang Zhang; Jun Ma; Lanwei Ouyang; Hongmei Chu; Huan Gao; Wenjing He; Tianhu Liu; Gang Li Journal: Front Public Health Date: 2022-07-18
Authors: Peter J Mazzone; Gerard A Silvestri; Lesley H Souter; Tanner J Caverly; Jeffrey P Kanne; Hormuzd A Katki; Renda Soylemez Wiener; Frank C Detterbeck Journal: Chest Date: 2021-07-13 Impact factor: 9.410