Literature DB >> 3198232

Looking ahead: algebraic thinking about genetics, cell kinetics and cancer.

W G Thilly1.   

Abstract

The cancer cell phenotype is modelled as a set of necessary genetic changes containing from one to three changes for any particular set of developmentally identical cells (tissue). This analysis suggests that a person in whose tissue an early genetic change occurs during ontogeny will perforce have a markedly higher number of cells in single sectors containing the necessary set of genetic changes. It is hypothesized that this numerical expectation is a dominant factor in determining the probability that a particular person will develop a tumour in a particular tissue.

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Year:  1988        PMID: 3198232

Source DB:  PubMed          Journal:  IARC Sci Publ        ISSN: 0300-5038


  4 in total

1.  A developmental hypothesis to explain the multicentricity of breast cancer.

Authors:  C R Sharpe
Journal:  CMAJ       Date:  1998-07-14       Impact factor: 8.262

2.  Age-dependent accumulation of recombinant cells in the mouse pancreas revealed by in situ fluorescence imaging.

Authors:  Dominika M Wiktor-Brown; Carrie A Hendricks; Werner Olipitz; Bevin P Engelward
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-01       Impact factor: 11.205

3.  Human fetal/tumor metakaryotic stem cells: pangenomic homologous pairing and telomeric end-joining of chromatids.

Authors:  Amanda N Gruhl; Elena V Gostjeva; William G Thilly; Janna N Fomina; Firouz Darroudi
Journal:  Cancer Genet Cytogenet       Date:  2010-12

Review 4.  Mutator/Hypermutable fetal/juvenile metakaryotic stem cells and human colorectal carcinogenesis.

Authors:  Lohith G Kini; Pablo Herrero-Jimenez; Tushar Kamath; Jayodita Sanghvi; Efren Gutierrez; David Hensle; John Kogel; Rebecca Kusko; Karl Rexer; Ray Kurzweil; Paulo Refinetti; Stephan Morgenthaler; Vera V Koledova; Elena V Gostjeva; William G Thilly
Journal:  Front Oncol       Date:  2013-10-29       Impact factor: 6.244

  4 in total

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