| Literature DB >> 3198232 |
Abstract
The cancer cell phenotype is modelled as a set of necessary genetic changes containing from one to three changes for any particular set of developmentally identical cells (tissue). This analysis suggests that a person in whose tissue an early genetic change occurs during ontogeny will perforce have a markedly higher number of cells in single sectors containing the necessary set of genetic changes. It is hypothesized that this numerical expectation is a dominant factor in determining the probability that a particular person will develop a tumour in a particular tissue.Entities:
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Year: 1988 PMID: 3198232
Source DB: PubMed Journal: IARC Sci Publ ISSN: 0300-5038