Siqing Li1, Yuan Liu1, Zehao Huang2, Yan Kou2, Ailing Hu3. 1. The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. 2. The Sun Yet-sen University, Guangzhou, China. 3. The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: h-ailing@163.com.
Abstract
OBJECTIVE: The purpose of this meta-analysis was to assess the efficacy and safety of nano-silver dressing combined with recombinant human epidermal growth factor for deep second-degree burns. METHODS: PubMed, Web of Science, EMBASE, Cochrane Library and other databases were searched to identify relevant randomised controlled trials. RESULTS: Twelve studies that assessed nano-silver dressing combined with recombinant human epidermal growth factor were identified. Nano-silver dressing combined with recombinant human epidermal growth factor for deep second-degree burns could significantly reduce the duration of wound healing (mean difference -5.68, 95% CI -7.38 - -3.99, P<0.00001), the wound healing rate (risk ratio [RR] 0.34, 95% CI 0.23-0.48, P<0.00001), the rate of scar hyperplasia (RR 0.67, 95% CI 0.54-0.84, P=0.0004), the wound bacterial positive rate (RR 0.50, 95% CI 0.28-0.89, P=0.02), and the adverse reactions rate (RR 0.31, 95% CI 0.16-0.58, P=0.0003). CONCLUSION: This comprehensive meta-analysis of the available evidence suggest that the use of nano-silver dressing combined with recombinant human epidermal growth factor results in shorter duration of wound healing, reduced wound bacterial positive rates and adverse reactions rate, and improved wound healing rates.
OBJECTIVE: The purpose of this meta-analysis was to assess the efficacy and safety of nano-silver dressing combined with recombinant humanepidermal growth factor for deep second-degree burns. METHODS: PubMed, Web of Science, EMBASE, Cochrane Library and other databases were searched to identify relevant randomised controlled trials. RESULTS: Twelve studies that assessed nano-silver dressing combined with recombinant humanepidermal growth factor were identified. Nano-silver dressing combined with recombinant humanepidermal growth factor for deep second-degree burns could significantly reduce the duration of wound healing (mean difference -5.68, 95% CI -7.38 - -3.99, P<0.00001), the wound healing rate (risk ratio [RR] 0.34, 95% CI 0.23-0.48, P<0.00001), the rate of scar hyperplasia (RR 0.67, 95% CI 0.54-0.84, P=0.0004), the wound bacterial positive rate (RR 0.50, 95% CI 0.28-0.89, P=0.02), and the adverse reactions rate (RR 0.31, 95% CI 0.16-0.58, P=0.0003). CONCLUSION: This comprehensive meta-analysis of the available evidence suggest that the use of nano-silver dressing combined with recombinant humanepidermal growth factor results in shorter duration of wound healing, reduced wound bacterial positive rates and adverse reactions rate, and improved wound healing rates.
Authors: Dan Yu; Di-Xiao Yang; Yao Li; Bi Guan; Qian Ming; Yan Li; Yi-Ping Zhu; Li-Qing Chen; Wei-Xiang Luo Journal: Cancer Manag Res Date: 2021-12-06 Impact factor: 3.989
Authors: María Florencia Sanchez; María Laura Guzman; Jesica Flores-Martín; Mariano Cruz Del Puerto; Carlos Laino; Elio Andrés Soria; Ana Carolina Donadio; Susana Genti-Raimondi; María Eugenia Olivera Journal: Sci Rep Date: 2022-09-26 Impact factor: 4.996