Long Chen1, Julia Li Zhong2. 1. Bioengineering Institute of Chongqing University, 174 Shazheng Street, Chongqing, China. 2. Bioengineering Institute of Chongqing University, 174 Shazheng Street, Chongqing, China. Electronic address: lzhong@cqu.edu.cn.
Abstract
BACKGROUND: Cumulative evidence suggests that in allergic diseases, oxidative stress and inflammation could often be detected. Therefore, the antioxidant/anti-inflammatory heme oxygenase (HO)-1 was recognized as a protective factor in allergic disorders. However, the precise underlying mechanisms of HO-1-based protection are not yet completely understood. In addition, miRNAs, a class of non-coding RNA, have been confirmed to associate with immunologic and inflammatory disorders in allergy recently. In addition, abundant studies have verified there is a complex connection between HO-1 and miRNAs. Thus, in this review, the combination of HO-1 and miRNAs (e.g. miR-155) in anti-allergy would be introduced. METHODS: To further confirm our hypothesis, GEO sequencing datasets of atopic dermatitis children were analyzed. The miR-548a-3p might regulate the cellular response to hydrogen peroxide through HO-1 and HIF-1pathway. Meanwhile, this article reviews the latest knowledge and studies on the protective mechanisms of miRNA-HO-1 in allergy. RESULTS: In brief, we supposed that miRNAs/HO-1 could mediate allergy through oxidative stress pathways, transcription factors and immune cell functions such as mast cell maturation, chemokine expression in T cell and dendritic cell degranulation. Although the detailed mechanism needs further research, this review may reveal the potential application of miRNAs and HO-1 in genetic therapies of allergic disease and provide new biomarkers. CONCLUSION: This article examines the latest knowledge and studies on the protective roles and mechanisms of miRNA-HO-1 in allergy. Moreover, via bioinformatics analysis of GEO dataset, it was demonstrated that miRNAs (e.g. miR-205, miR-203, and miR-483-5p) could regulate allergy process through HO-1.
BACKGROUND: Cumulative evidence suggests that in allergic diseases, oxidative stress and inflammation could often be detected. Therefore, the antioxidant/anti-inflammatory heme oxygenase (HO)-1 was recognized as a protective factor in allergic disorders. However, the precise underlying mechanisms of HO-1-based protection are not yet completely understood. In addition, miRNAs, a class of non-coding RNA, have been confirmed to associate with immunologic and inflammatory disorders in allergy recently. In addition, abundant studies have verified there is a complex connection between HO-1 and miRNAs. Thus, in this review, the combination of HO-1 and miRNAs (e.g. miR-155) in anti-allergy would be introduced. METHODS: To further confirm our hypothesis, GEO sequencing datasets of atopic dermatitischildren were analyzed. The miR-548a-3p might regulate the cellular response to hydrogen peroxide through HO-1 and HIF-1pathway. Meanwhile, this article reviews the latest knowledge and studies on the protective mechanisms of miRNA-HO-1 in allergy. RESULTS: In brief, we supposed that miRNAs/HO-1 could mediate allergy through oxidative stress pathways, transcription factors and immune cell functions such as mast cell maturation, chemokine expression in T cell and dendritic cell degranulation. Although the detailed mechanism needs further research, this review may reveal the potential application of miRNAs and HO-1 in genetic therapies of allergic disease and provide new biomarkers. CONCLUSION: This article examines the latest knowledge and studies on the protective roles and mechanisms of miRNA-HO-1 in allergy. Moreover, via bioinformatics analysis of GEO dataset, it was demonstrated that miRNAs (e.g. miR-205, miR-203, and miR-483-5p) could regulate allergy process through HO-1.