Literature DB >> 3198118

Assignment of human platelet GP2B (GPIIb) gene to chromosome 17, region q21.1-q21.3.

N V Cong1, G Uzan, M S Gross, C Jegou-Foubert, P Frachet, C Boucheix, G Marguerie, J Frézal.   

Abstract

The platelet GPIIb-IIIa complex functions as a receptor for fibrinogen, fibronectin, and von Willebrand factor on activated platelets. This glycoprotein is a member of a broadly distributed family of structurally and immunologically related membrane receptors involved in cell-cell contact and cell-matrices interactions. GPIIb-IIIa is a heterodimer complex composed of GPIIb (the alpha subunit), which consists of two disulfide-linked heavy and light chains, and GPIIIa (the beta subunit), which is a single polypeptide chain. Congenital absence of platelet GPIIb-IIIa in Glanzmann's thrombasthenia results in a severe bleeding disorder characterized by defective platelet aggregation and failure of fibrinogen to bind to platelets. The gene coding for GPIIb was located on 17q21.1-17q21.3 as determined by in situ hybridization with a 2650-bp GP2B (GPIIb) cDNA probe prepared from human megakaryocytes.

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Year:  1988        PMID： 3198118     DOI： 10.1007/bf00273658

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  26 in total

Review 1.  Integrins: a family of cell surface receptors.

Authors:  R O Hynes
Journal:  Cell       Date:  1987-02-27       Impact factor: 41.582

2.  Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors.

Authors:  R Pytela; M D Pierschbacher; M H Ginsberg; E F Plow; E Ruoslahti
Journal:  Science       Date:  1986-03-28       Impact factor: 47.728

3.  cDNA clones for human platelet GPIIb corresponding to mRNA from megakaryocytes and HEL cells. Evidence for an extensive homology to other Arg-Gly-Asp adhesion receptors.

Authors:  G Uzan; P Frachet; A Lajmanovich; M H Prandini; E Denarier; A Duperray; J Loftus; M Ginsberg; E Plow; G Marguerie
Journal:  Eur J Biochem       Date:  1988-01-15

4.  An abnormal platelet glycoprotein pattern in three cases of Glanzmann's thrombasthenia.

Authors:  A T Nurden; J P Caen
Journal:  Br J Haematol       Date:  1974-10       Impact factor: 6.998

5.  Platelet plasma membrane glycoproteins. Evidence for the presence of nonequivalent disulfide bonds using nonreduced-reduced two-dimensional gel electrophoresis.

Authors:  D R Phillips; P P Agin
Journal:  J Biol Chem       Date:  1977-03-25       Impact factor: 5.157

6.  Efficient isolation of genes by using antibody probes.

Authors:  R A Young; R W Davis
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

7.  An international system for human cytogenetic nomenclature--high-resolution banding (1981). ISCN (1981). Report of the Standing Committee on Human Cytogenetic Nomenclature.

Authors: 
Journal:  Cytogenet Cell Genet       Date:  1981

8.  Purification of glycoproteins IIb and III from human platelet plasma membranes and characterization of a calcium-dependent glycoprotein IIb-III complex.

Authors:  L K Jennings; D R Phillips
Journal:  J Biol Chem       Date:  1982-09-10       Impact factor: 5.157

9.  Immunochemical and amino-terminal sequence comparison of two cytoadhesins indicates they contain similar or identical beta subunits and distinct alpha subunits.

Authors:  M H Ginsberg; J Loftus; J J Ryckwaert; M Pierschbacher; R Pytela; E Ruoslahti; E F Plow
Journal:  J Biol Chem       Date:  1987-04-25       Impact factor: 5.157

10.  Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes.

Authors:  A Duperray; R Berthier; E Chagnon; J J Ryckewaert; M Ginsberg; E Plow; G Marguerie
Journal:  J Cell Biol       Date:  1987-06       Impact factor: 10.539
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