Literature DB >> 31980250

Identifying Missing Biosynthesis Enzymes of Plant Natural Products.

Thomas Dugé de Bernonville1, Nicolas Papon2, Marc Clastre1, Sarah E O'Connor3, Vincent Courdavault4.   

Abstract

Elucidating plant-specialized biosynthetic pathways has always constituted a laborious task, notably for natural products with high pharmaceutical values. Here, we discuss emerging omics-based strategies that facilitate the identification of genes from these complex metabolic pathways, paving the way to engineered supplies of these compounds through synthetic biology approaches.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Keywords:  RNA-seq; coexpression network; gene identification; specialized metabolites; whole genome sequencing

Year:  2020        PMID： 31980250     DOI： 10.1016/j.tips.2019.12.006

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  6 in total

1.  Predicting Monoterpene Indole Alkaloid-Related Genes from Expression Data with Artificial Neural Networks.

Authors:  Thomas Dugé de Bernonville; Emily Amor Stander; Géraud Dugé de Bernonville; Sébastien Besseau; Vincent Courdavault
Journal:  Methods Mol Biol       Date:  2022

2.  Cellular and Subcellular Compartmentation of the 2C-Methyl-D-Erythritol 4-Phosphate Pathway in the Madagascar Periwinkle.

Authors:  Grégory Guirimand; Anthony Guihur; Catalina Perello; Michael Phillips; Samira Mahroug; Audrey Oudin; Thomas Dugé de Bernonville; Sébastien Besseau; Arnaud Lanoue; Nathalie Giglioli-Guivarc'h; Nicolas Papon; Benoit St-Pierre; Manuel Rodríguez-Concepcíon; Vincent Burlat; Vincent Courdavault
Journal:  Plants (Basel)       Date:  2020-04-07

3.  Identifying Genes Involved in alkaloid Biosynthesis in Vinca minor Through Transcriptomics and Gene Co-Expression Analysis.

Authors:  Emily Amor Stander; Liuda Johana Sepúlveda; Thomas Dugé de Bernonville; Inês Carqueijeiro; Konstantinos Koudounas; Pamela Lemos Cruz; Sébastien Besseau; Arnaud Lanoue; Nicolas Papon; Nathalie Giglioli-Guivarc'h; Ron Dirks; Sarah Ellen O'Connor; Lucia Atehortùa; Audrey Oudin; Vincent Courdavault
Journal:  Biomolecules       Date:  2020-11-24

4.  Engineering cellular metabolite transport for biosynthesis of computationally predicted tropane alkaloid derivatives in yeast.

Authors:  Prashanth Srinivasan; Christina D Smolke
Journal:  Proc Natl Acad Sci U S A       Date:  2021-06-22       Impact factor: 11.205

Review 5.  Review of Machine Learning Methods for the Prediction and Reconstruction of Metabolic Pathways.

Authors:  Hayat Ali Shah; Juan Liu; Zhihui Yang; Jing Feng
Journal:  Front Mol Biosci       Date:  2021-06-17

6.  Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila.

Authors:  Mengquan Yang; Qiang Wang; Yining Liu; Xiaolong Hao; Can Wang; Yuchen Liang; Jianbo Chen; Youli Xiao; Guoyin Kai
Journal:  BMC Biol       Date:  2021-06-16       Impact factor: 7.431
  6 in total

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