Lingguo Bu1, Liping Qi2, Wu Yan3, Qian Yan3, Zekun Tang3, Furong Li4, Xin Liu5, Chunfeng Diao5, Kefeng Li6, Guijun Dong7. 1. School of Mechanical and Aerospace Engineering, Nanyang Technological University, 639798, Singapore; Key Laboratory of High Efficiency and Clean Mechanical Manufacture, School of Mechanical Engineering, Shandong University, Jinan, 250061, China. 2. School of Biomedical Engineering, Dalian University of Technology, Dalian, 116024, China. 3. Shandong Sport University, Jinan, 250102, China. 4. Female Compulsory Isolation Drug Rehabilitation Center of Shandong Province, Zibo, 255311, China. 5. Drug Rehabilitation Administration of Shandong Province, Jinan, 250014, China. 6. Shandong Sport University, Jinan, 250102, China. Electronic address: jmlikefeng@163.com. 7. Shandong Sport University, Jinan, 250102, China. Electronic address: donggj@163.com.
Abstract
OBJECTIVE: Methamphetamine (METH) dependence, especially among women, is a serious global health problem. Kick-boxing exercise can be used to reduce cue-induced craving and develop a healthy lifestyle for female with METH dependencies. This study aimed to assess acute kick-boxing related changes in effective connectivity (EC) in the brain of females with METH dependencies by using functional near-infrared spectroscopy (fNIRS) signals. METHODS: The fNIRS signals were continuously recorded from the left and right prefrontal cortices (LPFC/RPFC) and left and right motor cortices (LMC/RMC) of 30 female subjects with methamphetamine dependencies (METH group) and 30 age-matched controls (control group) during resting and kick-boxing exercise (training) periods. EC was calculated in the frequency range of 0.01-0.08 Hz. RESULTS: In both resting and training state, the EC levels of METH group were significantly lower than the control group (p < 0.05). The EC levels of control group showed more significantly increased connection types than that of the METH group. CONCLUSION: Acute kick-boxing exercise altered EC in the brain of females with METH dependencies. Furthermore, the efficiency of the information flow between different brain regions in the control group was significantly higher than that in the METH group. This study provides a novel and portable assessment technique for METH rehabilitation in females on the basis of fNIRS signals.
OBJECTIVE:Methamphetamine (METH) dependence, especially among women, is a serious global health problem. Kick-boxing exercise can be used to reduce cue-induced craving and develop a healthy lifestyle for female with METH dependencies. This study aimed to assess acute kick-boxing related changes in effective connectivity (EC) in the brain of females with METH dependencies by using functional near-infrared spectroscopy (fNIRS) signals. METHODS: The fNIRS signals were continuously recorded from the left and right prefrontal cortices (LPFC/RPFC) and left and right motor cortices (LMC/RMC) of 30 female subjects with methamphetamine dependencies (METH group) and 30 age-matched controls (control group) during resting and kick-boxing exercise (training) periods. EC was calculated in the frequency range of 0.01-0.08 Hz. RESULTS: In both resting and training state, the EC levels of METH group were significantly lower than the control group (p < 0.05). The EC levels of control group showed more significantly increased connection types than that of the METH group. CONCLUSION: Acute kick-boxing exercise altered EC in the brain of females with METH dependencies. Furthermore, the efficiency of the information flow between different brain regions in the control group was significantly higher than that in the METH group. This study provides a novel and portable assessment technique for METH rehabilitation in females on the basis of fNIRS signals.