| Literature DB >> 31978408 |
Iuliia A Polina1, Daria V Ilatovskaya1, Kristine Y DeLeon-Pennell2.
Abstract
Release of cell free DNA (cfDNA) from damaged or dead cells routinely occurs in normal physiology. Recently, cfDNA has emerged as an essential biomarker in cardiovascular disease (CVD) of potential prognostic and diagnostic significance. Within the last decade, significant research efforts have been devoted to uncovering the mechanisms mediating cfDNA release and its outcome-predicting ability. The current review focuses on the pathways for cfDNA release in myocardial infarction, heart failure and hypertension, and discusses implementation of cfDNA monitoring to assess the overall development of these disease states and predict future complications. Published by Elsevier B.V.Entities:
Keywords: Cardiovascular disease; Inflammation; MMPs; cfDNA
Mesh:
Substances:
Year: 2020 PMID: 31978408 PMCID: PMC7042038 DOI: 10.1016/j.cca.2020.01.013
Source DB: PubMed Journal: Clin Chim Acta ISSN: 0009-8981 Impact factor: 3.786