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Literature DB >> 3197802

Fructose-1,6-diphosphate reduces acute ECG changes due to doxorubicin in isolated rat heart.

N Bernardini¹, R Danesi, M C Bernardini, M Del Tacca.

Abstract

Doxorubicin (DXR) (0.17 x 10(-4) M) induces an acute cardiotoxicity in isolated rat heart; there is a progressive widening of the S alpha T segment, with a decrease in force derivatives and in the coronary flow. Concurrent perfusion with fructose-1,6-diphosphate (FDP) (10(-5)-10(-4) M) dose-dependently reduces the S alpha T enlargement but fails to affect the reduction in force derivatives and coronary flow. The target of cardiac protection by FDP might be the ionic mechanisms underlying the action potential configuration.

Entities: Chemical Disease Species

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Year: 1988 PMID： 3197802 DOI： 10.1007/bf01939901

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

17 in total

1. An analysis of the action of ATP and related compounds on membrane current and tension components in bullfrog atrial muscle.

Authors: M Goto; A Yatani; Y Tsuda
Journal: Jpn J Physiol Date: 1977

Review 2. The anthracycline antineoplastic drugs.

Authors: R C Young; R F Ozols; C E Myers
Journal: N Engl J Med Date: 1981-07-16 Impact factor: 91.245

3. Experimental animal models of adriamycin cardiotoxicity.

Authors: J H Doroshow; G Y Locker; C E Myers
Journal: Cancer Treat Rep Date: 1979-05

4. Mechanism of acute anthracycline cardiotoxicity in isolated rat hearts: carminomycin versus daunomycin.

Authors: S Saman; P Jacobs; L H Opie
Journal: Cancer Res Date: 1984-04 Impact factor: 12.701

5. The influence of amrinone on cardiac toxicity induced by adriamycin in rats.

Authors: C Bernardini; M Del Tacca; R Danesi; P Della Torre
Journal: Arch Int Pharmacodyn Ther Date: 1986-10

6. Effect of anthracycline antibiotics on oxygen radical formation in rat heart.

Authors: J H Doroshow
Journal: Cancer Res Date: 1983-02 Impact factor: 12.701

7. Doxorubicin cardiotoxicity in the rat: comparison of electrocardiogram, transmembrane potential, and structural effects.

Authors: R A Jensen; E M Acton; J H Peters
Journal: J Cardiovasc Pharmacol Date: 1984 Jan-Feb Impact factor: 3.105

Fructose-1,6-diphosphate reduces acute ECG changes due to doxorubicin in isolated rat heart.

1. An analysis of the action of ATP and related compounds on membrane current and tension components in bullfrog atrial muscle.

Review 2. The anthracycline antineoplastic drugs.

3. Experimental animal models of adriamycin cardiotoxicity.

4. Mechanism of acute anthracycline cardiotoxicity in isolated rat hearts: carminomycin versus daunomycin.

5. The influence of amrinone on cardiac toxicity induced by adriamycin in rats.

6. Effect of anthracycline antibiotics on oxygen radical formation in rat heart.

7. Doxorubicin cardiotoxicity in the rat: comparison of electrocardiogram, transmembrane potential, and structural effects.

8. Irreversible hemorrhagic shock: treatment and cardiac pathophysiology.

9. Effects of adriamycin on the macromolecular synthesis in rat myocardiocytes and KB cells.

10. Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo.

1. Protective effects of fructose-1,6-diphosphate on acute and chronic doxorubicin cardiotoxicity in rats.