Silpa D Krefft1, Jenna Wolff, Lauren Zell-Baran, Matthew Strand, Eva Brigitte Gottschall, Richard Meehan, Cecile Stephanie Rose. 1. National Jewish Health, Denver (Dr Krefft, Ms Wolff, Ms Zell-Baran, Dr Strand, Dr Gottschall, Dr Meehan, Dr Rose); Veterans Administration Eastern Colorado Health Care System (Dr Krefft); University of Colorado Anschutz Medical Campus (Dr Krefft, Dr Rose); Colorado School of Public Health (Dr Krefft, Ms Zell-Baran, Dr Strand, Dr Rose); University of Colorado (Dr Gottschall, Dr Meehan), Aurora, Colorado.
Abstract
OBJECTIVE: Persistent respiratory symptoms following post-9/11 military deployment to Iraq and Afghanistan are well-recognized, but the spectrum of respiratory diseases remains poorly characterized. This study describes deployment-related respiratory diseases and the diagnostic utility of resting and exercise pulmonary function testing. METHODS: Between 2009 and 2017, 127 consecutive military workers ("deployers") with new-onset respiratory symptoms underwent clinical evaluation. Deployment-related respiratory diseases were classified as proximal and/or distal. Using descriptive statistics and logistic regression, we analyzed lung function parameters associated with deployment-related distal lung disease (DDLD). RESULTS: Common deployment-related respiratory diseases included asthma (31.5%), intermittent laryngeal obstruction (14.2%), rhinosinusitis (15%), and DDLD (68.5%). Decreased diffusion capacity (odds ratio [OR] = 4.6, 95% confidence interval [CI]: 1.4 to 15.1, P = 0.01) was significantly associated with DDLD. CONCLUSIONS: A comprehensive diagnostic approach may identify a spectrum of proximal and distal respiratory diseases that can occur in symptomatic post-9/11 deployers, requiring a personalized approach to care.
OBJECTIVE: Persistent respiratory symptoms following post-9/11 military deployment to Iraq and Afghanistan are well-recognized, but the spectrum of respiratory diseases remains poorly characterized. This study describes deployment-related respiratory diseases and the diagnostic utility of resting and exercise pulmonary function testing. METHODS: Between 2009 and 2017, 127 consecutive military workers ("deployers") with new-onset respiratory symptoms underwent clinical evaluation. Deployment-related respiratory diseases were classified as proximal and/or distal. Using descriptive statistics and logistic regression, we analyzed lung function parameters associated with deployment-related distal lung disease (DDLD). RESULTS: Common deployment-related respiratory diseases included asthma (31.5%), intermittent laryngeal obstruction (14.2%), rhinosinusitis (15%), and DDLD (68.5%). Decreased diffusion capacity (odds ratio [OR] = 4.6, 95% confidence interval [CI]: 1.4 to 15.1, P = 0.01) was significantly associated with DDLD. CONCLUSIONS: A comprehensive diagnostic approach may identify a spectrum of proximal and distal respiratory diseases that can occur in symptomatic post-9/11 deployers, requiring a personalized approach to care.
Authors: Lauren M Zell-Baran; Silpa D Krefft; Camille M Moore; Jenna Wolff; Richard Meehan; Cecile S Rose Journal: Respir Med Date: 2020-12-05 Impact factor: 3.415
Authors: Christopher J Hill; Charles D Meyer; James E McLean; Danielle C Anderson; Yajing Hao; Feng-Chang Lin; Adam J Kimple; Gregory G Capra Journal: J Occup Environ Med Date: 2022-06-09 Impact factor: 2.306
Authors: Seagal Teitz-Tennenbaum; Steven P Viglianti; Ahmad Jomma; Quentin Palone; Halia Andrews; Kayla N Selbmann; Shayanki Lahiri; Natalia Subbotina; Natalie Walker; Anne-Karina T Perl; Vibha N Lama; Thomas H Sisson; John J Osterholzer Journal: Am J Pathol Date: 2021-12-23 Impact factor: 4.307
Authors: Reena Berman; Elysia Min; Jie Huang; Katrina Kopf; Gregory P Downey; Kent Riemondy; Harry A Smith; Cecile S Rose; Max A Seibold; Hong Wei Chu; Brian J Day Journal: Toxicol Sci Date: 2021-08-03 Impact factor: 4.109
Authors: Lauren M Zell-Baran; Stephen M Humphries; Camille M Moore; David A Lynch; Jean-Paul Charbonnier; Andrea S Oh; Cecile S Rose Journal: BMC Pulm Med Date: 2022-04-27 Impact factor: 3.320
Authors: Silpa D Krefft; Andrea Oh; Lauren M Zell-Baran; Jenna Wolff; Camille M Moore; Tony V Macedonia; Cecile S Rose Journal: J Thorac Imaging Date: 2022-03-01 Impact factor: 3.000