| Literature DB >> 3197730 |
A J van der Heijden1, W F Grose, J J Ambagtsheer, A P Provoost, E D Wolff, P J Sauer.
Abstract
In 41 preterm neonates with a gestational age (GA) varying from 27 to 36 weeks, glomerular filtration rate (GFR) was measured by means of the continuous inulin infusion technique. The reliability of the technique was confirmed. During postnatal development GFR was found to increase in two ways: firstly, an increase with advancing gestational age, associated with the increase in body weight (BW) [GFR (ml/min) = 0.15 X GA-3.20, r = 0.48, P = 0.0048]; secondly, a postnatal increase, being independent from increment in BW. An increase in GFR (ml/min.kg) from 0.88 +/- 0.23 to 1.18 +/- 0.28 was observed between day 4 and day 11 postnatally (P less than 0.008). This latter increase is probably associated with changes in renal haemodynamics. No significant influence of artificial ventilation on GFR could be demonstrated in preterm neonates.Entities:
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Year: 1988 PMID： 3197730 DOI： 10.1007/bf00441807
Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183