| Literature DB >> 31977297 |
Noah A Brown1, Kojo S J Elenitoba-Johnson2.
Abstract
Genomic testing enables clinical management to be tailored to individual cancer patients based on the molecular alterations present within cancer cells. Genomic sequencing results can be applied to detect and classify cancer, predict prognosis, and target therapies. Next-generation sequencing has revolutionized the field of cancer genomics by enabling rapid and cost-effective sequencing of large portions of the genome. With this technology, precision oncology is quickly becoming a realized paradigm for managing the treatment of cancer patients. However, many challenges must be overcome to efficiently implement the transition of next-generation sequencing from research applications to routine clinical practice, including using specimens commonly available in the clinical setting; determining how to process, store, and manage large amounts of sequencing data; determining how to interpret and prioritize molecular findings; and coordinating health professionals from multiple disciplines.Entities:
Keywords: cancer; molecular pathology; next-generation sequencing; personalized medicine; precision medicine; precision oncology
Mesh:
Year: 2020 PMID: 31977297 DOI: 10.1146/annurev-pathmechdis-012418-012735
Source DB: PubMed Journal: Annu Rev Pathol ISSN: 1553-4006 Impact factor: 23.472