Literature DB >> 31977297

Enabling Precision Oncology Through Precision Diagnostics.

Noah A Brown1, Kojo S J Elenitoba-Johnson2.   

Abstract

Genomic testing enables clinical management to be tailored to individual cancer patients based on the molecular alterations present within cancer cells. Genomic sequencing results can be applied to detect and classify cancer, predict prognosis, and target therapies. Next-generation sequencing has revolutionized the field of cancer genomics by enabling rapid and cost-effective sequencing of large portions of the genome. With this technology, precision oncology is quickly becoming a realized paradigm for managing the treatment of cancer patients. However, many challenges must be overcome to efficiently implement the transition of next-generation sequencing from research applications to routine clinical practice, including using specimens commonly available in the clinical setting; determining how to process, store, and manage large amounts of sequencing data; determining how to interpret and prioritize molecular findings; and coordinating health professionals from multiple disciplines.

Entities:  

Keywords:  cancer; molecular pathology; next-generation sequencing; personalized medicine; precision medicine; precision oncology

Mesh:

Year:  2020        PMID: 31977297     DOI: 10.1146/annurev-pathmechdis-012418-012735

Source DB:  PubMed          Journal:  Annu Rev Pathol        ISSN: 1553-4006            Impact factor:   23.472


  13 in total

Review 1.  Application Progress of High-Throughput Sequencing in Ocular Diseases.

Authors:  Xuejun He; Ningzhi Zhang; Wenye Cao; Yiqiao Xing; Ning Yang
Journal:  J Clin Med       Date:  2022-06-17       Impact factor: 4.964

2.  Urinary detection of early responses to checkpoint blockade and of resistance to it via protease-cleaved antibody-conjugated sensors.

Authors:  Quoc D Mac; Anirudh Sivakumar; Hathaichanok Phuengkham; Congmin Xu; James R Bowen; Fang-Yi Su; Samuel Z Stentz; Hyoungjun Sim; Adrian M Harris; Tonia T Li; Peng Qiu; Gabriel A Kwong
Journal:  Nat Biomed Eng       Date:  2022-03-03       Impact factor: 29.234

Review 3.  Delivering precision oncology to patients with cancer.

Authors:  Joaquin Mateo; Lotte Steuten; Philippe Aftimos; Fabrice André; Mark Davies; Elena Garralda; Jan Geissler; Don Husereau; Iciar Martinez-Lopez; Nicola Normanno; Jorge S Reis-Filho; Stephen Stefani; David M Thomas; C Benedikt Westphalen; Emile Voest
Journal:  Nat Med       Date:  2022-04-19       Impact factor: 87.241

4.  Implementation of a Molecular Tumor Registry to Support the Adoption of Precision Oncology Within an Academic Medical Center: The Duke University Experience.

Authors:  Michelle F Green; Jonathan L Bell; Christopher B Hubbard; Shannon J McCall; Matthew S McKinney; Jinny E Riedel; Carolyn S Menendez; James L Abbruzzese; John H Strickler; Michael B Datto
Journal:  JCO Precis Oncol       Date:  2021-09-16

5.  Accessing Targeted Therapies: A Potential Roadblock to Implementing Precision Oncology?

Authors:  Mitchell S von Itzstein; Mary L Smith; Elda Railey; Carol B White; Julianne S Dieterich; Liz Garrett-Mayer; Suanna S Bruinooge; Andrew N Freedman; Janet De Moor; Stacy W Gray; Jason Y Park; Jingsheng Yan; Anh Quynh Hoang; Hong Zhu; David E Gerber
Journal:  JCO Oncol Pract       Date:  2021-05-10

6.  Comprehensive and Computable Molecular Diagnostic Panel (C2Dx) From Small Volume Specimens for Precision Oncology: Molecular Subtyping of Non-Small Cell Lung Cancer From Fine Needle Aspirates.

Authors:  Jing Su; Lynn S Huang; Ryan Barnard; Graham Parks; James Cappellari; Christina Bellinger; Travis Dotson; Lou Craddock; Bharat Prakash; Jonathan Hovda; Hollins Clark; William Jeffrey Petty; Boris Pasche; Michael D Chan; Lance D Miller; Jimmy Ruiz
Journal:  Front Oncol       Date:  2021-04-16       Impact factor: 6.244

7.  Real-World Performance of a Comprehensive Genomic Profiling Test Optimized for Small Tumor Samples.

Authors:  Scott A Tomlins; Daniel H Hovelson; Jennifer M Suga; Daniel M Anderson; Han A Koh; Elizabeth C Dees; Brendan McNulty; Mark E Burkard; Michael Guarino; Jamil Khatri; Malek M Safa; Marc R Matrana; Eddy S Yang; Alex R Menter; Benjamin M Parsons; Jennifer N Slim; Michael A Thompson; Leon Hwang; William J Edenfield; Suresh Nair; Adedayo Onitilo; Robert Siegel; Alan Miller; Timothy Wassenaar; William J Irvin; William Schulz; Arvinda Padmanabhan; Vallathucherry Harish; Anneliese Gonzalez; Abdul Hai Mansoor; Andrew Kellum; Paul Harms; Stephanie Drewery; Jayson Falkner; Andrew Fischer; Jennifer Hipp; Kat Kwiatkowski; Lorena Lazo de la Vega; Khalis Mitchell; Travis Reeder; Javed Siddiqui; Hana Vakil; D Bryan Johnson; Daniel R Rhodes
Journal:  JCO Precis Oncol       Date:  2021-08-19

8.  Clinical Validity of Circulating Tumor DNA as Prognostic and Predictive Marker for Personalized Colorectal Cancer Patient Management.

Authors:  Ariane Hallermayr; Verena Steinke-Lange; Holger Vogelsang; Markus Rentsch; Maike de Wit; Christopher Haberl; Elke Holinski-Feder; Julia M A Pickl
Journal:  Cancers (Basel)       Date:  2022-02-08       Impact factor: 6.639

9.  TUGDA: task uncertainty guided domain adaptation for robust generalization of cancer drug response prediction from in vitro to in vivo settings.

Authors:  Rafael Peres da Silva; Chayaporn Suphavilai; Niranjan Nagarajan
Journal:  Bioinformatics       Date:  2021-05-17       Impact factor: 6.937

10.  What is ahead for health policy and technology in the 2020s?

Authors:  Donald R J Singer; Ken Redekop
Journal:  Health Policy Technol       Date:  2020-02-05
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