| Literature DB >> 31976834 |
Luiz Claudio Ferreira Pimentel1,2, Anna Claudia Cunha2, Lucas Villas Boas Hoelz1, Henayle Fernandes Canzian1, Debora Inacio Leite Firmino Marinho1, Nubia Boechat1, Monica Macedo Bastos1.
Abstract
The phenylamino-pyrimidine (PAP) nucleus has been demonstrated to be useful for the development of new drugs and is present in a wide variety of antiretroviral agents and tyrosine kinase inhibitors (TKIs). This review aims to evaluate the application of PAP derivatives in drugs and other bioactive compounds. It was concluded that PAP derivatives are still worth exploring, as they may provide highly competitive ATP TKI's with nano/picomolar activity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: ATP; Antiretroviral; Cancer; PAP; Pyrimidine; Tyrosine kinase.
Year: 2020 PMID： 31976834 DOI： 10.2174/1568026620666200124094949
Source DB: PubMed Journal: Curr Top Med Chem ISSN： 1568-0266 Impact factor: 3.295