Tzong-Hann Yang1,2,3, Sudha Xirasagar4, Yen-Fu Cheng2,5,6,7, Chuan-Song Wu1, Yi-Wei Kao8, Ben-Chang Shia8, Herng-Ching Lin9,10. 1. Department of Otorhinolaryngology, Taipei City Hospital, Taipei. 2. Department of Speech, Language and Audiology, National Taipei University of Nursing and Health. 3. Research Center of Sleep Medicine, College of Medicine, Taipei Medical University, Taipei. 4. Department of Health Services Policy and Management, Arnold School of Public Health, University of South Carolina, Columbia, USA. 5. Department of Medical Research, Taipei Veterans General Hospital, Taipei. 6. Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei. 7. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, National Yang-Ming University, Taipei. 8. Big Data Research Center, Taipei Medical University, Taipei. 9. Sleep Research Center, Taipei Medical University Hospital, Taipei. 10. School of Health Care Administration, College of Management, Taipei Medical University, Taipei.
Abstract
OBJECTIVE: Despite studies reporting a possible association between malignant otitis externa (MOE) and diabetes, there are no large-scale population-based empirical studies. This nationwide, population-based case-control study explored the association of MOE occurrence with previously diagnosed diabetes. METHODS: Data were retrieved from Taiwan's National Health Insurance Research Database, 753 patients with MOE (cases) and 2 259 propensity score-matched patients without MOE (controls). Multiple logistic regressions were conducted to examine the association of MOE with previously diagnosed diabetes. RESULTS: In total, 728 (24.2%) out of 3 012 sample patients had diabetes prior to the index date. Chi-square test revealed a significant difference in diabetes prevalence among cases and controls (54.8% vs 13.9%, p < 0.001). Simple logistic regression showed the odds ratio for prior diabetes among cases versus controls was 7.50 (95% CI, 6.22~9.03). The adjusted odds ratio of prior diabetes for cases versus controls was 10.07 (95% CI, 8.15~12.44) after adjusting for patient demographics and medical co-morbidities. CONCLUSIONS: This study found an association between MOE and diabetes. One clinical practice implication of our study is that when a patient with diabetes complains of otalgia or otorrhea, and physical examination shows swelling of the ear canal or granulation growth, physicians should consider the possibility of MOE.
OBJECTIVE: Despite studies reporting a possible association between malignant otitis externa (MOE) and diabetes, there are no large-scale population-based empirical studies. This nationwide, population-based case-control study explored the association of MOE occurrence with previously diagnosed diabetes. METHODS: Data were retrieved from Taiwan's National Health Insurance Research Database, 753 patients with MOE (cases) and 2 259 propensity score-matched patients without MOE (controls). Multiple logistic regressions were conducted to examine the association of MOE with previously diagnosed diabetes. RESULTS: In total, 728 (24.2%) out of 3 012 sample patients had diabetes prior to the index date. Chi-square test revealed a significant difference in diabetes prevalence among cases and controls (54.8% vs 13.9%, p < 0.001). Simple logistic regression showed the odds ratio for prior diabetes among cases versus controls was 7.50 (95% CI, 6.22~9.03). The adjusted odds ratio of prior diabetes for cases versus controls was 10.07 (95% CI, 8.15~12.44) after adjusting for patient demographics and medical co-morbidities. CONCLUSIONS: This study found an association between MOE and diabetes. One clinical practice implication of our study is that when a patient with diabetes complains of otalgia or otorrhea, and physical examination shows swelling of the ear canal or granulation growth, physicians should consider the possibility of MOE.
Authors: S H Hodgson; V J Sinclair; J Arwyn-Jones; K Oh; K Nucken; M Perenyei; V Sivapathasingam; P Martinez-Devesa; S T Pendlebury; J D Ramsden; P C Matthews; P Pretorius; M I Andersson Journal: J Laryngol Otol Date: 2022-01-19 Impact factor: 2.187