Leila Farhad-Mollashahi1, Marieh Honarmand2, Alireza Nakhaee3, Shahram Kamalzadeh4, Sanaz Amini4. 1. Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 2. Oral and Dental Disease Research Center, Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. 3. Department of Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. 4. Dentist, Zahedan University of Medical Sciences, Zahedan, Iran.
Abstract
BACKGROUND: Recurrent aphthous stomatitis is a common oral mucosa disease, with no specific etiology. Atopy has been implicated in the development of this disease. In this study, the salivary levels of immunoglobulin E (IgE) and eosinophil cationic protein (ECP) were measured as allergy-related biomarkers in patients with aphthous stomatitis. MATERIAL AND METHODS: In this case-control study, non-stimulated saliva was collected from 85 participants and IgE and ECP were measured. Data were analyzed in SPSS 20 through the Mann-Whitney test, and p<0.05 was considered significant. RESULTS: The salivary levels of IgE and ECP were 1.11±0.65 Iu/ml and 26.93±6.95 ng/ml in the case group and 0.73±0/39 Iu/ml and 21.97±6.72 ng/ml in the control group. There was a significant difference between the two groups in terms of salivary levels of IgE and ECP (p=0.001). CONCLUSIONS: The results showed that patients with oral aphthous had higher levels of salivary IgE and ECP than controls. Therefore, measurement of these biomarkers may be useful in the initial evaluation of patients with aphthous stomatitis. Key words:Recurrent aphthous stomatitis, saliva, immunoglobulin E, eosinophil cationic protein. Copyright:
BACKGROUND: Recurrent aphthous stomatitis is a common oral mucosa disease, with no specific etiology. Atopy has been implicated in the development of this disease. In this study, the salivary levels of immunoglobulin E (IgE) and eosinophil cationic protein (ECP) were measured as allergy-related biomarkers in patients with aphthous stomatitis. MATERIAL AND METHODS: In this case-control study, non-stimulated saliva was collected from 85 participants and IgE and ECP were measured. Data were analyzed in SPSS 20 through the Mann-Whitney test, and p<0.05 was considered significant. RESULTS: The salivary levels of IgE and ECP were 1.11±0.65 Iu/ml and 26.93±6.95 ng/ml in the case group and 0.73±0/39 Iu/ml and 21.97±6.72 ng/ml in the control group. There was a significant difference between the two groups in terms of salivary levels of IgE and ECP (p=0.001). CONCLUSIONS: The results showed that patients with oral aphthous had higher levels of salivary IgE and ECP than controls. Therefore, measurement of these biomarkers may be useful in the initial evaluation of patients with aphthous stomatitis. Key words:Recurrent aphthous stomatitis, saliva, immunoglobulin E, eosinophil cationic protein. Copyright:
Authors: Laura B Huling; Lorena Baccaglini; Linda Choquette; Richard S Feinn; Rajesh V Lalla Journal: J Oral Pathol Med Date: 2011-11-12 Impact factor: 4.253
Authors: S S Natah; Y T Konttinen; N S Enattah; N Ashammakhi; K A Sharkey; R Häyrinen-Immonen Journal: Int J Oral Maxillofac Surg Date: 2004-04 Impact factor: 2.789