| Literature DB >> 31974314 |
Kim Dore1, Yvonne Pao1, Jose Soria Lopez1, Sage Aronson1, Huiqing Zhan2, Sanchari Ghosh2, Sabina Merrill2, Anthony M Zador2, Roberto Malinow3, Justus M Kebschull4,5,6.
Abstract
Which neural circuits undergo synaptic changes when an animal learns? Although it is widely accepted that changes in synaptic strength underlie many forms of learning and memory, it remains challenging to connect changes in synaptic strength at specific neural pathways to specific behaviors and memories. Here we introduce SYNPLA (synaptic proximity ligation assay), a synapse-specific, high-throughput, and potentially brain-wide method capable of detecting circuit-specific learning-induced synaptic plasticity.Keywords: GluA1; defense conditioning; fear conditioning; proximity ligation assay; synaptic potentiation
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Year: 2020 PMID： 31974314 PMCID： PMC7022215 DOI： 10.1073/pnas.1919911117
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205