H Maral1, E Ertekin2, Ö Tunçyürek2,3, Y Özsunar2. 1. From the Department of Radiology (H.M.), Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey. 2. Department of Radiology (E.E., Ö.T., Y.Ö.), Aydın Adnan Menderes University Faculty of Medicine, Aydın, Turkey. 3. Department of Radiology (Ö.T.), Near East University Faculty of Medicine, Nicosia, Cyprus.
Abstract
BACKGROUND AND PURPOSE: Our aim was to investigate the effects of intratumoral hemorrhage, calcification, and postoperative changes on the sensitivity of arterial spin-labeling and DSC perfusion MR imaging in patients with primary brain tumors. MATERIALS AND METHODS: Eighty-six brain tumor lesions were examined with single-phase and multiphase arterial spin-labeling and DSC perfusion MR imaging. The lesions that had no intratumoral bleeding/calcifications and history of surgery were assigned to group 1 (n = 38), and the lesions that had these were assigned to group 2 (n = 48). The relative regional cerebral blood flow was calculated in both perfusion methods, and relative regional cerebral blood volume was calculated in DSC. Imaging results were correlated with histopathology or follow-up. RESULTS: In the quantitative evaluation, the sensitivity and specificity of relative regional cerebral blood flow in multiphase arterial spin-labeling perfusion were 94.4% and 80% in group 1 and 78.3% and 88% in group 2, respectively. The sensitivity and specificity of relative regional cerebral blood flow in DSC perfusion were 88.9% and 75% in group 1 and 78.3% and 84% in group 2, respectively. The sensitivity and specificity of relative regional cerebral blood volume in DSC perfusion were 66.7% and 100% in group 1 and 69.6% and 96% in group 2, respectively. In the qualitative evaluation, the sensitivities for single-phase and multiphase arterial spin-labeling were 48.2% and 79.3%, respectively, with 100% specificity for both. CONCLUSIONS: The sensitivity and specificity of multiphase arterial spin-labeling were similar to those of DSC perfusion irrespective of bleeding and calcification in primary brain tumors. Thus, we suggest that noncontrast multiphase arterial spin-labeling can be used instead of DSC perfusion MR imaging in the diagnosis and follow-up of intracranial tumors.
BACKGROUND AND PURPOSE: Our aim was to investigate the effects of intratumoral hemorrhage, calcification, and postoperative changes on the sensitivity of arterial spin-labeling and DSC perfusion MR imaging in patients with primary brain tumors. MATERIALS AND METHODS: Eighty-six brain tumor lesions were examined with single-phase and multiphase arterial spin-labeling and DSC perfusion MR imaging. The lesions that had no intratumoral bleeding/calcifications and history of surgery were assigned to group 1 (n = 38), and the lesions that had these were assigned to group 2 (n = 48). The relative regional cerebral blood flow was calculated in both perfusion methods, and relative regional cerebral blood volume was calculated in DSC. Imaging results were correlated with histopathology or follow-up. RESULTS: In the quantitative evaluation, the sensitivity and specificity of relative regional cerebral blood flow in multiphase arterial spin-labeling perfusion were 94.4% and 80% in group 1 and 78.3% and 88% in group 2, respectively. The sensitivity and specificity of relative regional cerebral blood flow in DSC perfusion were 88.9% and 75% in group 1 and 78.3% and 84% in group 2, respectively. The sensitivity and specificity of relative regional cerebral blood volume in DSC perfusion were 66.7% and 100% in group 1 and 69.6% and 96% in group 2, respectively. In the qualitative evaluation, the sensitivities for single-phase and multiphase arterial spin-labeling were 48.2% and 79.3%, respectively, with 100% specificity for both. CONCLUSIONS: The sensitivity and specificity of multiphase arterial spin-labeling were similar to those of DSC perfusion irrespective of bleeding and calcification in primary brain tumors. Thus, we suggest that noncontrast multiphase arterial spin-labeling can be used instead of DSC perfusion MR imaging in the diagnosis and follow-up of intracranial tumors.
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