Paul H Fischer1, Marten Marra2, Caroline B Ameling2, Guus J M Velders3, Ronald Hoogerbrugge2, Wilco de Vries2, Joost Wesseling2, Nicole A H Janssen2, Danny Houthuijs2. 1. National Institute for Public Health and the Environment, Bilthoven, the Netherlands. Electronic address: paul.fischer@rivm.nl. 2. National Institute for Public Health and the Environment, Bilthoven, the Netherlands. 3. National Institute for Public Health and the Environment, Bilthoven, the Netherlands; Institute for Marine and Atmospheric Research Utrecht, Utrecht University, the Netherlands.
Abstract
BACKGROUND: Long-term exposure to particulate air pollution has been associated with mortality in urban cohort studies. Few studies have investigated the association between emission contributions from different particle sources and mortality in large-scale population registries, including non-urban populations. OBJECTIVES: The aim of the study was to evaluate the associations between long-term exposure to particulate air pollution from different source categories and non-accidental mortality in the Netherlands based on existing national databases. METHODS: We used existing Dutch national databases on mortality, individual characteristics, residence history, neighbourhood characteristics and modelled air pollution concentrations from different sources and air pollution components: particulate matter PM10, primary particulate matter PM10 (PPM10), particulate matter PM2.5, primary particulate matter PM2.5 (PPM2.5), elemental carbon (EC), nitrogen dioxide (NO2) and secondary inorganic aerosol (SIA) in PM10 (SIA10) or in PM2.5 (SIA2.5). We established a cohort of 7.5 million individuals 30 years or older. We followed the cohort for eight years (2008-2015). We applied Cox proportional hazard regression models adjusting for potential individual and area-specific confounders. RESULTS: We found statistically significant associations between total and primary particulate matter (PM10 and PM2.5), elemental carbon and mortality. Adjustment for nitrogen dioxide did not change the associations. Secondary inorganic aerosol showed less consistent associations. All primary PM sources were associated with mortality, except agricultural emissions and, depending on the statistical model, industrial PM emissions. CONCLUSIONS: We could not identify one or more specific source categories of particulate air pollution as main determinants of the mortality effects found in this and in a previous study. This suggests that present policy measures should be focussed on the wider spectrum of air pollution sources instead of on specific sources.
BACKGROUND: Long-term exposure to particulate air pollution has been associated with mortality in urban cohort studies. Few studies have investigated the association between emission contributions from different particle sources and mortality in large-scale population registries, including non-urban populations. OBJECTIVES: The aim of the study was to evaluate the associations between long-term exposure to particulate air pollution from different source categories and non-accidental mortality in the Netherlands based on existing national databases. METHODS: We used existing Dutch national databases on mortality, individual characteristics, residence history, neighbourhood characteristics and modelled air pollution concentrations from different sources and air pollution components: particulate matter PM10, primary particulate matter PM10 (PPM10), particulate matter PM2.5, primary particulate matter PM2.5 (PPM2.5), elemental carbon (EC), nitrogen dioxide (NO2) and secondary inorganic aerosol (SIA) in PM10 (SIA10) or in PM2.5 (SIA2.5). We established a cohort of 7.5 million individuals 30 years or older. We followed the cohort for eight years (2008-2015). We applied Cox proportional hazard regression models adjusting for potential individual and area-specific confounders. RESULTS: We found statistically significant associations between total and primary particulate matter (PM10 and PM2.5), elemental carbon and mortality. Adjustment for nitrogen dioxide did not change the associations. Secondary inorganic aerosol showed less consistent associations. All primary PM sources were associated with mortality, except agricultural emissions and, depending on the statistical model, industrial PM emissions. CONCLUSIONS: We could not identify one or more specific source categories of particulate air pollution as main determinants of the mortality effects found in this and in a previous study. This suggests that present policy measures should be focussed on the wider spectrum of air pollution sources instead of on specific sources.
Authors: Jie Chen; Gerard Hoek; Kees de Hoogh; Sophia Rodopoulou; Zorana J Andersen; Tom Bellander; Jørgen Brandt; Daniela Fecht; Francesco Forastiere; John Gulliver; Ole Hertel; Barbara Hoffmann; Ulla Arthur Hvidtfeldt; W M Monique Verschuren; Karl-Heinz Jöckel; Jeanette T Jørgensen; Klea Katsouyanni; Matthias Ketzel; Diego Yacamán Méndez; Karin Leander; Shuo Liu; Petter Ljungman; Elodie Faure; Patrik K E Magnusson; Gabriele Nagel; Göran Pershagen; Annette Peters; Ole Raaschou-Nielsen; Debora Rizzuto; Evangelia Samoli; Yvonne T van der Schouw; Sara Schramm; Gianluca Severi; Massimo Stafoggia; Maciej Strak; Mette Sørensen; Anne Tjønneland; Gudrun Weinmayr; Kathrin Wolf; Emanuel Zitt; Bert Brunekreef; George D Thurston Journal: Environ Sci Technol Date: 2022-06-23 Impact factor: 11.357