Dominique Haumont1, Neena Modi2, Ola D Saugstad3, Rosine Antetere4, Cuong NguyenBa4, Mark Turner5, Kate Costeloe6, Willem Aelvoet4. 1. Saint-Pierre University Hospital, Brussels, Belgium. Dominique_Haumont@stpierre-bru.be. 2. Section of Neonatal Medicine, Chelsea and Westminster Hospital Campus, Imperial College London, London, UK. 3. Department of Pediatric Research, University of Oslo, Oslo, Norway. 4. eNewborn International Network, Brussels, Belgium. 5. University of Liverpool, Liverpool, England. 6. Queen Mary University of London, London, UK.
Abstract
BACKGROUND: The inefficiency of recording data repeatedly limits the number of studies conducted. Here we illustrate the wider use of data captured as part of the European eNewborn benchmarking programme. METHODS: We extracted data on 39,529 live-births from 22 weeks 0 days to 31 weeks 6 days gestational age (GA) or ≤1500 g birth weight. We explored relationships between delivery room care and Apgar scores on mortality and bronchopulmonary dysplasia (BPD) and calculated the time needed for each country to detect a clinically relevant change in these outcomes following a hypothetical intervention. RESULTS: Early neonatal, neonatal, and in-hospital mortality were 3.90% (95% CI 3.71, 4.09), 6.00% (5.77, 6.24) and 7.57% (7.31, 7.83), respectively. The odds of death were greater with decreasing GA, lower Apgar scores, growth restriction, male sex, multiple birth and no antenatal steroids. Relationships for BPD were similar. The time required for participating countries to achieve 80% power to detect a relevant change in outcomes following a hypothetical intervention in 23-25 weeks' GA infants ranged from 12 years for neonatal mortality and 22 years for BPD compared to 1 year for the whole network. CONCLUSIONS: The eNewborn platform offers opportunity to drive efficiencies in benchmarking, quality control and research.
BACKGROUND: The inefficiency of recording data repeatedly limits the number of studies conducted. Here we illustrate the wider use of data captured as part of the European eNewborn benchmarking programme. METHODS: We extracted data on 39,529 live-births from 22 weeks 0 days to 31 weeks 6 days gestational age (GA) or ≤1500 g birth weight. We explored relationships between delivery room care and Apgar scores on mortality and bronchopulmonary dysplasia (BPD) and calculated the time needed for each country to detect a clinically relevant change in these outcomes following a hypothetical intervention. RESULTS: Early neonatal, neonatal, and in-hospital mortality were 3.90% (95% CI 3.71, 4.09), 6.00% (5.77, 6.24) and 7.57% (7.31, 7.83), respectively. The odds of death were greater with decreasing GA, lower Apgar scores, growth restriction, male sex, multiple birth and no antenatal steroids. Relationships for BPD were similar. The time required for participating countries to achieve 80% power to detect a relevant change in outcomes following a hypothetical intervention in 23-25 weeks' GA infants ranged from 12 years for neonatal mortality and 22 years for BPD compared to 1 year for the whole network. CONCLUSIONS: The eNewborn platform offers opportunity to drive efficiencies in benchmarking, quality control and research.
Authors: Vishal Kapadia; Ju Lee Oei; Neil Finer; Wade Rich; Yacov Rabi; Ian M Wright; Denise Rook; Marijn J Vermeulen; William O Tarnow-Mordi; John P Smyth; Kei Lui; Steven Brown; Ola D Saugstad; Maximo Vento Journal: Resuscitation Date: 2021-08-20 Impact factor: 6.251