Amélie Darlix1, Valérie Rigau2, Julien Fraisse2, Catherine Gozé2, Michel Fabbro2, Hugues Duffau2. 1. From the Department of Medical Oncology (A.D., M.F.) and Biometrics Unit (J.F.), Institut du Cancer de Montpellier, University of Montpellier; INSERM U1051 (A.D., V.R., C.G., H.D.), Montpellier Neurosciences Institute; and Department of Pathology (V.R.), Pathology and Oncobiology Department, Laboratory of Solid Tumors Biology (C.G.), and Department of Neurosurgery (H.D.), Montpellier University Hospital, France. amelie.darlix@icm.unicancer.fr. 2. From the Department of Medical Oncology (A.D., M.F.) and Biometrics Unit (J.F.), Institut du Cancer de Montpellier, University of Montpellier; INSERM U1051 (A.D., V.R., C.G., H.D.), Montpellier Neurosciences Institute; and Department of Pathology (V.R.), Pathology and Oncobiology Department, Laboratory of Solid Tumors Biology (C.G.), and Department of Neurosurgery (H.D.), Montpellier University Hospital, France.
Abstract
OBJECTIVE: Diffuse low-grade gliomas (DLGG) are defined by continuous growth and an almost unavoidable malignant transformation. Foci of malignant glioma can be found within DLGG samples obtained from surgical resections. As the medical management of patients is classically based on the higher tumor grade, an immediate adjuvant treatment is usually proposed. To determine whether postponing the medical treatment in selected patients is feasible, we conducted a single-center retrospective study. METHODS: This was a single-center retrospective analysis of a consecutive series of DLGG managed with this conservative strategy. Inclusion criteria were at least 1 focus of malignant tumor (grade III-IV, WHO 2016), no previous chemotherapy or radiotherapy, no less than a subtotal resection of the fluid-attenuated inversion recovery tumor volume, no intention of treating with immediate adjuvant therapy, and minimum 2 years of follow-up. The time interval to the following oncologic medical treatment was analyzed, as well as the functional and survival results. RESULTS: Forty-four patients met the inclusion criteria (median age 36, median time interval from diagnosis 7 months). Most tumors (88%) were IDH-mutant and 1p19q intact (59%); 9 presented with grade IV foci. With a median follow-up of 6.7 years, 75% of patients received a subsequent medical treatment, after a median time of 3.4 years since surgery. At the time of analysis, 9 patients (20.0%) had died (5- and 7-year survival rates: 95% and 67.0%). Most surviving patients were still active professionally, without seizures. CONCLUSIONS: Postponing the medical treatment in DLGG with foci of malignant tumor following total or subtotal resection should be considered in selected patients.
OBJECTIVE: Diffuse low-grade gliomas (DLGG) are defined by continuous growth and an almost unavoidable malignant transformation. Foci of malignant glioma can be found within DLGG samples obtained from surgical resections. As the medical management of patients is classically based on the higher tumor grade, an immediate adjuvant treatment is usually proposed. To determine whether postponing the medical treatment in selected patients is feasible, we conducted a single-center retrospective study. METHODS: This was a single-center retrospective analysis of a consecutive series of DLGG managed with this conservative strategy. Inclusion criteria were at least 1 focus of malignant tumor (grade III-IV, WHO 2016), no previous chemotherapy or radiotherapy, no less than a subtotal resection of the fluid-attenuated inversion recovery tumor volume, no intention of treating with immediate adjuvant therapy, and minimum 2 years of follow-up. The time interval to the following oncologic medical treatment was analyzed, as well as the functional and survival results. RESULTS: Forty-four patients met the inclusion criteria (median age 36, median time interval from diagnosis 7 months). Most tumors (88%) were IDH-mutant and 1p19q intact (59%); 9 presented with grade IV foci. With a median follow-up of 6.7 years, 75% of patients received a subsequent medical treatment, after a median time of 3.4 years since surgery. At the time of analysis, 9 patients (20.0%) had died (5- and 7-year survival rates: 95% and 67.0%). Most surviving patients were still active professionally, without seizures. CONCLUSIONS: Postponing the medical treatment in DLGG with foci of malignant tumor following total or subtotal resection should be considered in selected patients.
Authors: Lucas Alverne F Albuquerque; João Paulo Almeida; Leonardo José Monteiro de Macêdo Filho; Andrei F Joaquim; Hugues Duffau Journal: Neurosurg Rev Date: 2020-08-07 Impact factor: 3.042
Authors: S Relier; A Amalric; A Attina; I B Koumare; V Rigau; F Burel Vandenbos; D Fontaine; M Baroncini; J P Hugnot; H Duffau; L Bauchet; C Hirtz; E Rivals; A David Journal: Anal Chem Date: 2022-08-23 Impact factor: 8.008