Literature DB >> 3196905

Long-term observation of rats after unilateral intra-amygdaloid injection of kainic acid.

S Tanaka1, S Kondo, T Tanaka, Y Yonemasu.   

Abstract

Electroencephalographic and clinical observations of the rats were done for 3 months after microinjection of kainic acid (KA, 0.2-1.2 micrograms) into the unilateral amygdala. With high doses of KA (0.6-1.2 micrograms) injection, 64% of rats developed spontaneous limbic seizures 14-25 days after KA injection. Among those which developed spontaneous limbic seizures, 33% of rats developed secondarily generalized seizures 26-71 days after KA injection. This is one of the best chronic models of spontaneous complex partial seizure secondarily generalized in rats, which is economical and easy to prepare.

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Year:  1988        PMID： 3196905     DOI： 10.1016/0006-8993(88)90541-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

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2.  Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn2+ Accumulation and Its Entry into and Prolonged Effects on Mitochondria.

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Journal:  J Neurosci       Date:  2022-05-27       Impact factor: 6.709

4.  Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis.

Authors:  Mark Dunleavy; Sachiko Shinoda; Clara Schindler; Claire Ewart; Ross Dolan; Oliviero L Gobbo; Christian M Kerskens; David C Henshall
Journal:  Am J Pathol       Date:  2009-11-30       Impact factor: 4.307

Review 5.  Posttraumatic epilepsy: hemorrhage, free radicals and the molecular regulation of glutamate.

Authors:  L J Willmore; Yuto Ueda
Journal:  Neurochem Res       Date:  2008-09-11       Impact factor: 3.996

6.  Kainic acid seizures in the rat: differential expression of chromogranin A, carboxypeptidase H and peptidylglycine alpha-amidating monooxigenase in subfields of the hippocampal formation.

Authors:  S K Mahata; B Gruber; M Mahata; C Röder; R Fischer-Colbrie; G Sperk
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

7.  Zn2+ entry through the mitochondrial calcium uniporter is a critical contributor to mitochondrial dysfunction and neurodegeneration.

Authors:  Sung G Ji; Yuliya V Medvedeva; John H Weiss
Journal:  Exp Neurol       Date:  2019-12-24       Impact factor: 5.330

8.  Long non-coding RNA H19 contributes to apoptosis of hippocampal neurons by inhibiting let-7b in a rat model of temporal lobe epilepsy.

Authors:  Chun-Lei Han; Ming Ge; Yun-Peng Liu; Xue-Min Zhao; Kai-Liang Wang; Ning Chen; Wei Hu; Jian-Guo Zhang; Liang Li; Fan-Gang Meng
Journal:  Cell Death Dis       Date:  2018-05-23       Impact factor: 8.469

9.  Ripple-related firing of identified deep CA1 pyramidal cells in chronic temporal lobe epilepsy in mice.

Authors:  Ivan Marchionni; Michelle Oberoi; Ivan Soltesz; Allyson Alexander
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  9 in total

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