Glutathione Bioresponsive Cyclodextrin Nanosponges.

Cyclodextrin-based nanosponges are designed as new nanostructured material for drug delivery. In vitro and in vivo studies show that nanosponges can increase the effectiveness of anti-cancer drugs encapsulated within their nanostructure. Reported is a new, cheap glutathione (GSH)-responsive material easily obtained in high yield through a one-step synthetic route. Effectiveness of this GSH-responsive material was proved using several tumor cells and doxorubicin as model anticancer drug. The release of the drug was in according with the GSH content in tumor cells.