High expression of LAMP1 as a prognostic marker in patients with epithelial ovarian cancer.

Lysosome Associated Membrane Protein-1 (LAMP1), expressed in several functional processes, is a heavily glycosylated lysosomal membrane protein which is able to protect the lysosomal membranes from intracellular proteolysis. Its pro-tumorigenic effects are involved in the development of several types of Malignancy. However, the role of LAMP1 in human Epithelial Ovarian Cancer (EOC) patients remains unclear. To demonstrate its prognostic significance in EOC, the methods of RT-PCR and IHC were used to evaluate LAMP1 expression in both EOC and nonmalignant tissues. What's more, the relationship between LAMP1 and clinicopathological factors was investigated. Survival analysis was used to elaborate its prognostic value. Expression of LAMP1 in tumor cells in EOC was significantly higher than those in noncancerous tissues. LAMP1 over-expression in EOC was significantly related to FIGO stage, metastasis invasion, positive ascites cell and the level of serum CA125. The Kaplan-Meier plot and Cox regression method have shown that LAMP1 over-expression in EOC and FIGO stage was significantly related to malignant features in EOC and EOC patients' unfavorable survival. It was strongly evidenced in our research that LAMP1 is a prognostic factor in EOC. Our results suggest that LAMP1 could be used as a poor prognostic factor and novel therapeutic target for EOC. IJCEP