Elena Favaretto1, Giulia Gortani2, Gabriele Simonini3, Serena Pastore2, Alberto Di Mascio1, Rolando Cimaz3, Andrea Taddio4,5. 1. University of Trieste, Piazzale Europa 2, 34100, Trieste, Italy. 2. Institute for Maternal and Child Health-IRCCS, "Burlo Garofolo"-Via dell'Istria 65/1, 34100, Trieste, Italy. 3. Rheumatology Unit, Anna Meyer Children's Hospital, University of Florence, Viale Pieraccini 24, 50139, Florence, Italy. 4. University of Trieste, Piazzale Europa 2, 34100, Trieste, Italy. andrea.taddio@burlo.trieste.it. 5. Institute for Maternal and Child Health-IRCCS, "Burlo Garofolo"-Via dell'Istria 65/1, 34100, Trieste, Italy. andrea.taddio@burlo.trieste.it.
Abstract
The objective of the study is to evaluate the efficacy of corticosteroids in Sydenham chorea. This is a retrospective observational study. Clinical information of children with Sydenham chorea were collected. Outcome of Sydenham chorea was evaluated in consideration of presence or absence of corticosteroid therapy. Thirty patients were enrolled. A total of 15 were treated with prednisone, 15 received symptomatic drugs or no treatment. Patients who were treated with prednisone showed faster improvement (4 vs 16 days; p = 0.002) and shorter median time of remission (30 vs 135 days; p < 0.001). Conclusion: Our study showed that corticosteroid therapy is an effective treatment of Sydenham chorea.What is Known:• Steroid treatment in Sydenham chorea is widely used but it is not standardized.• Few manuscript report a beneficial use of steroids in Sydenham chorea if compared with no treatment.What is New:• Steroid treatment seems to be effective in both clinical remission and clinical improvement of symptoms among patients with Sydenham chorea.• Steroid treatment seems to be superior to conventional treatment.
The objective of the study is to evaluate the efficacy of corticosteroids in Sydenham chorea. This is a retrospective observational study. Clinical information of children with Sydenham chorea were collected. Outcome of Sydenham chorea was evaluated in consideration of presence or absence of corticosteroid therapy. Thirty patients were enrolled. A total of 15 were treated with prednisone, 15 received symptomatic drugs or no treatment. Patients who were treated with prednisone showed faster improvement (4 vs 16 days; p = 0.002) and shorter median time of remission (30 vs 135 days; p < 0.001). Conclusion: Our study showed that corticosteroid therapy is an effective treatment of Sydenham chorea.What is Known:• Steroid treatment in Sydenham chorea is widely used but it is not standardized.• Few manuscript report a beneficial use of steroids in Sydenham chorea if compared with no treatment.What is New:• Steroid treatment seems to be effective in both clinical remission and clinical improvement of symptoms among patients with Sydenham chorea.• Steroid treatment seems to be superior to conventional treatment.
Authors: Achille Marino; Rolando Cimaz; Maria Antonietta Pelagatti; Giulia Tattesi; Andrea Biondi; Laura Menni; Marco Sala; Patrizia Calzi; Francesco Morandi; Francesca Cortinovis; Anna Cogliardi; Claudia Addis; Roberto Bellù; Massimo Andreotti; Tiziana Varisco Journal: Front Med (Lausanne) Date: 2021-02-24
Authors: Alessandro Orsini; Thomas Foiadelli; Attilio Sica; Andrea Santangelo; Niccolò Carli; Alice Bonuccelli; Rita Consolini; Sofia D'Elios; Nicolò Loddo; Alberto Verrotti; Giuseppe Di Cara; Chiara Marra; Maria Califano; Anna Fetta; Marianna Fabi; Stefania Bergamoni; Aglaia Vignoli; Roberta Battini; Marta Mosca; Chiara Baldini; Nadia Assanta; Pietro Marchese; Gabriele Simonini; Edoardo Marrani; Francesca Felicia Operto; Grazia Maria Giovanna Pastorino; Salvatore Savasta; Giuseppe Santangelo; Virginia Pedrinelli; Gabriele Massimetti; Liliana Dell'Osso; Diego Peroni; Duccio Maria Cordelli; Martina Corsi; Claudia Carmassi Journal: Int J Environ Res Public Health Date: 2022-08-25 Impact factor: 4.614