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Literature DB >> 31964761

Is CYP2C70 the key to new mouse models to understand bile acids in humans?

Grace L Guo¹, John Y L Chiang.

Abstract

Entities: Chemical Gene Species

Mesh：

Substances：
Bile Acids and Salts

Year: 2020 PMID： 31964761 PMCID： PMC7053840 DOI： 10.1194/jlr.C120000621

Source DB: PubMed Journal: J Lipid Res ISSN： 0022-2275 Impact factor: 5.922

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7 in total

1. Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.

Authors: Tiangang Li; Asmeen Jahan; John Y L Chiang
Journal: Hepatology Date: 2006-06 Impact factor: 17.425

2. Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase.

Authors: J H Miyake; S L Wang; R A Davis
Journal: J Biol Chem Date: 2000-07-21 Impact factor: 5.157

3. Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.

Authors: Akira Honda; Teruo Miyazaki; Junichi Iwamoto; Takeshi Hirayama; Yukio Morishita; Tadakuni Monma; Hajime Ueda; Seiya Mizuno; Fumihiro Sugiyama; Satoru Takahashi; Tadashi Ikegami
Journal: J Lipid Res Date: 2019-10-23 Impact factor: 5.922

Review 4. Animal models to study bile acid metabolism.

Authors: Jianing Li; Paul A Dawson
Journal: Biochim Biophys Acta Mol Basis Dis Date: 2018-05-18 Impact factor: 5.187

5. Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.

Authors: Asmeen Jahan; John Y L Chiang
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2004-11-18 Impact factor: 4.052

6. Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.

Authors: Shogo Takahashi; Tatsuki Fukami; Yusuke Masuo; Chad N Brocker; Cen Xie; Kristopher W Krausz; C Roland Wolf; Colin J Henderson; Frank J Gonzalez
Journal: J Lipid Res Date: 2016-09-16 Impact factor: 5.922

7. A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice.

Authors: Jan Freark de Boer; Esther Verkade; Niels L Mulder; Hilde D de Vries; Nicolette Huijkman; Martijn Koehorst; Theo Boer; Justina C Wolters; Vincent W Bloks; Bart van de Sluis; Folkert Kuipers
Journal: J Lipid Res Date: 2019-09-10 Impact factor: 5.922

7 in total

Is CYP2C70 the key to new mouse models to understand bile acids in humans?

1. Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.

2. Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase.

3. Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.

Review 4. Animal models to study bile acid metabolism.

5. Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.

6. Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.

7. A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice.

Review 1. Key Signaling in Alcohol-Associated Liver Disease: The Role of Bile Acids.

2. Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine.

Review 3. Improving glucose and lipids metabolism: drug development based on bile acid related targets.

Review 4. The Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease.

5. Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis.

6. Bile acids, bioactive signalling molecules in interoceptive gut-to-brain communication.

7. Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis.