Literature DB >> 3196333

Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase.

D A Robertson1, C Freeman, P V Nelson, C P Morris, J J Hopwood.   

Abstract

Glucosamine-6-sulfatase is a lysosomal enzyme which degrades glycosaminoglycans and is deficient in mucopolysaccharidosis type IIID. Human liver contains two major active forms of glucosamine-6-sulfatase, form A which has a single 78 kDa polypeptide and form B which has two polypeptides of 48 kDa and 32 kDa. A 1761 base pair cDNA clone encoding the complete 48 kDa polypeptide of form B was isolated. Form A is shown to be processed to form B with the 48 kDa polypeptide C-terminal to the 32 kDa polypeptide, and it is shown that C-terminal processing is limited to a region of thirty amino acids. The glucosamine-6-sulfatase sequence reveals homology with steroid sulfatase, a microsomal enzyme.

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Year:  1988        PMID： 3196333     DOI： 10.1016/s0006-291x(88)80035-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  14 in total

1.  Mucopolysaccharidosis IVA: four new exonic mutations in patients with N-acetylgalactosamine-6-sulfate sulfatase deficiency.

Authors:  S Tomatsu; S Fukuda; A Yamagishi; A Cooper; J F Wraith; T Hori; Z Kato; N Yamada; K Isogai; K Sukegawa; N Kondo; Y Suzuki; N Shimozawa; T Orii
Journal:  Am J Hum Genet       Date:  1996-05       Impact factor: 11.025

2.  Sanfilippo syndrome type D in two adolescent sisters.

Authors:  L Siciliano; A Fiumara; L Pavone; C Freeman; D Robertson; C P Morris; J J Hopwood; P Di Natale; S Musumeci; A L Horwitz
Journal:  J Med Genet       Date:  1991-06       Impact factor: 6.318

3.  alpha-Glucosidase and N-acetylglucosamine-6-sulphatase are the major mannose-6-phosphate glycoproteins in human urine.

Authors:  D E Sleat; S R Kraus; I Sohar; H Lackland; P Lobel
Journal:  Biochem J       Date:  1997-05-15       Impact factor: 3.857

4.  Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA.

Authors:  P J Wilson; C P Morris; D S Anson; T Occhiodoro; J Bielicki; P R Clements; J J Hopwood
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

5.  Purification of a 75 kDa protein from the organelle matrix of human neutrophils and identification as N-acetylglucosamine-6-sulphatase.

Authors:  Shengyuan Xu; Linshu Zhao; Anders Larsson; Emanuel Smeds; Marion Kusche-Gullberg; Per Venge
Journal:  Biochem J       Date:  2005-05-01       Impact factor: 3.857

6.  Human glucosamine-6-sulphatase deficiency. Diagnostic enzymology towards heparin-derived trisaccharide substrates.

Authors:  C Freeman; J J Hopwood
Journal:  Biochem J       Date:  1992-03-01       Impact factor: 3.857

7.  Identification of a common mutation (R245H) in Sanfilippo A patients from The Netherlands.

Authors:  B Weber; J J van de Kamp; W J Kleijer; X H Guo; L Blanch; O P van Diggelen; R Wevers; B J Poorthuis; J J Hopwood
Journal:  J Inherit Metab Dis       Date:  1998-06       Impact factor: 4.982

8.  Attempted enzyme replacement using human amnion membrane implantations in mucopolysaccharidoses.

Authors:  J Muenzer; E F Neufeld; G Constantopoulos; R C Caruso; M I Kaiser-Kupfer; A Pikus; J Danoff; R R Berry; H D McDonald; J N Thompson
Journal:  J Inherit Metab Dis       Date:  1992       Impact factor: 4.982

9.  Human alpha-L-iduronidase: cDNA isolation and expression.

Authors:  H S Scott; D S Anson; A M Orsborn; P V Nelson; P R Clements; C P Morris; J J Hopwood
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

10.  A cDNA clone for human glucosamine-6-sulphatase reveals differences between arylsulphatases and non-arylsulphatases.

Authors:  D A Robertson; C Freeman; C P Morris; J J Hopwood
Journal:  Biochem J       Date:  1992-12-01       Impact factor: 3.857
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