Ying Ying Leung1, Ana-Maria Orbai2, Maarten de Wit3, Andra Balanescu4, Emmanuelle Dernis5, Martin Soubrier6, Lihi Eder7, Josef S Smolen8, Laura C Coates9, Laure Gossec10. 1. Singapore General Hospital, Duke-National University of Singapore Medical School, Singapore. 2. John Hopkins University, Baltimore, Maryland. 3. Patient Research Partner, VU Medical Center, Amsterdam, The Netherlands. 4. Maria Hospital, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania. 5. Le Mans Central Hospital, Le Mans, France. 6. Gabriel Montpied Hospital, Clermont Ferrand, France. 7. Women's College Hospital, University of Toronto, Toronto, Ontario, Canada. 8. Medical University of Vienna, Vienna, Austria. 9. University of Oxford, Oxford, UK. 10. Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, and Pitié Salpêtrière Hospital, AP-HP, Paris, France.
Abstract
OBJECTIVE: We evaluated the psychometric properties of 3 patient-reported outcome measures to assess the physical function in psoriatic arthritis (PsA). METHODS: Data were available for the Health Assessment Questionnaire disability index (HAQ DI), the 12-item Short Form instrument physical component summary (SF-12 PCS), and the Psoriatic Arthritis Impact of Disease instrument functional capacity score (PsAID-FC). Data came from a longitudinal study in 14 countries of consecutive adults with definite PsA with ≥2 years of duration. The score distribution, construct validity, responsiveness, and thresholds of meaning of the patient-reported outcome measures were evaluated. RESULTS: At baseline, 414 subjects (52% male) were analyzed. The mean ± SD age was 52.4 ± 12.5 years and duration of illness was 10.9 ± 8.1 years. Ceiling effects were noted in 31% and 21% of patients for HAQ DI and PsAID-FC, respectively; floor effects were minimal. All 3 patient-reported outcome measures met a priori hypotheses for construct validity. After a median follow-up of 4.1 (interquartile range 2.7) months in 350 patients, 27%, 54%, and 18% of patients reported themselves improved, not changed, and worsened, respectively. Change scores were statistically different for groups for worsening versus no-change for all patient-reported outcome measures. PsAID-FC was more sensitive to change than the other 2 patient-reported outcome measures. Comparing groups with worsening condition to no-change, the standardized response mean square ratios were HAQ DI 29.9, SF-12 PCS 16.7, and PsAID-FC 40.1. CONCLUSION: HAQ DI, SF-12 PCS, and PsAID-FC are valid measures of physical function for PsA. PsAID-FC, a single question, performed similarly to the other patient-reported outcome measures and may be an additional option to measure PsA-specific physical function.
OBJECTIVE: We evaluated the psychometric properties of 3 patient-reported outcome measures to assess the physical function in psoriatic arthritis (PsA). METHODS: Data were available for the Health Assessment Questionnaire disability index (HAQ DI), the 12-item Short Form instrument physical component summary (SF-12 PCS), and the Psoriatic Arthritis Impact of Disease instrument functional capacity score (PsAID-FC). Data came from a longitudinal study in 14 countries of consecutive adults with definite PsA with ≥2 years of duration. The score distribution, construct validity, responsiveness, and thresholds of meaning of the patient-reported outcome measures were evaluated. RESULTS: At baseline, 414 subjects (52% male) were analyzed. The mean ± SD age was 52.4 ± 12.5 years and duration of illness was 10.9 ± 8.1 years. Ceiling effects were noted in 31% and 21% of patients for HAQ DI and PsAID-FC, respectively; floor effects were minimal. All 3 patient-reported outcome measures met a priori hypotheses for construct validity. After a median follow-up of 4.1 (interquartile range 2.7) months in 350 patients, 27%, 54%, and 18% of patients reported themselves improved, not changed, and worsened, respectively. Change scores were statistically different for groups for worsening versus no-change for all patient-reported outcome measures. PsAID-FC was more sensitive to change than the other 2 patient-reported outcome measures. Comparing groups with worsening condition to no-change, the standardized response mean square ratios were HAQ DI 29.9, SF-12 PCS 16.7, and PsAID-FC 40.1. CONCLUSION: HAQ DI, SF-12 PCS, and PsAID-FC are valid measures of physical function for PsA. PsAID-FC, a single question, performed similarly to the other patient-reported outcome measures and may be an additional option to measure PsA-specific physical function.
Authors: Dafna D Gladman; Philip J Mease; Vibeke Strand; Paul Healy; Philip S Helliwell; Oliver Fitzgerald; Alice B Gottlieb; Gerald G Krueger; Peter Nash; Christopher T Ritchlin; William Taylor; Ade Adebajo; Jurgen Braun; Alberto Cauli; Sueli Carneiro; Ernst Choy; Ben Dijkmans; Luiz Espinoza; Desiree van der Heijde; Elaine Husni; Ennio Lubrano; Dennis McGonagle; Abrar Qureshi; Enrique R Soriano; Jane Zochling Journal: J Rheumatol Date: 2007-05 Impact factor: 4.666
Authors: Ana-Maria Orbai; Maarten de Wit; Philip Mease; Judy A Shea; Laure Gossec; Ying Ying Leung; William Tillett; Musaab Elmamoun; Kristina Callis Duffin; Willemina Campbell; Robin Christensen; Laura Coates; Emma Dures; Lihi Eder; Oliver FitzGerald; Dafna Gladman; Niti Goel; Suzanne Dolwick Grieb; Sarah Hewlett; Pil Hoejgaard; Umut Kalyoncu; Chris Lindsay; Neil McHugh; Bev Shea; Ingrid Steinkoenig; Vibeke Strand; Alexis Ogdie Journal: Ann Rheum Dis Date: 2016-09-09 Impact factor: 19.103
Authors: E Passia; M Vis; L C Coates; A Soni; I Tchetverikov; A H Gerards; M R Kok; P A J M Vos; L Korswagen; F Fodili; Y P M Goekoop-Ruiterman; J van der Kaap; M van Oosterhout; J J Luime Journal: Arthritis Res Ther Date: 2022-01-11 Impact factor: 5.156