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Literature DB >> 31960843

A 'light-up' intercalator displacement assay for detection of triplex DNA stabilizers.

Imee M A Del Mundo¹, Eun Jeong Cho, Kevin N Dalby, Karen M Vasquez.

Abstract

Here, we developed a coralyne-based, 'light-up' intercalator displacement assay to identify molecular stabilizers of triplex DNA using a sequence from a chromosomal breakpoint hotspot in the human c-MYC oncogene. Its potential to identify triplex DNA ligands was demonstrated using BePI and doxorubicin. Identification of triplex-interacting ligands may allow the regulation of genetic instability in human genomes.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2020 PMID： 31960843 PMCID： PMC7323859 DOI： 10.1039/c9cc08817b

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

54 in total

1. Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: a comparative spectroscopic and calorimetric study.

Authors: Kakali Bhadra; Gopinatha Suresh Kumar
Journal: Biochim Biophys Acta Date: 2011-01-31

2. Microarray detection of duplex and triplex DNA binders with DNA-modified gold nanoparticles.

Authors: Abigail K R Lytton-Jean; Min Su Han; Chad A Mirkin
Journal: Anal Chem Date: 2007-07-06 Impact factor: 6.986

Review 3. Non-B DNA conformations, mutagenesis and disease.

Authors: Robert D Wells
Journal: Trends Biochem Sci Date: 2007-05-09 Impact factor: 13.807

4. Complete disproportionation of duplex poly(dT)poly(dA) into triplex poly(dT)poly(dA)*poly(dT) and poly(dA) by coralyne.

Authors: Matjaz Polak; Nicholas V Hud
Journal: Nucleic Acids Res Date: 2002-02-15 Impact factor: 16.971

1. Anomeric DNA Strand Displacement with α-D Oligonucleotides as Invaders and Ethidium Bromide as Fluorescence Sensor for Duplexes with α/β-, β/β- and α/α-D Configuration.

Authors: Aigui Zhang; Dasharath Kondhare; Peter Leonard; Frank Seela
Journal: Chemistry Date: 2022-07-04 Impact factor: 5.020

1 in total

A 'light-up' intercalator displacement assay for detection of triplex DNA stabilizers.

1. Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: a comparative spectroscopic and calorimetric study.

2. Microarray detection of duplex and triplex DNA binders with DNA-modified gold nanoparticles.

Review 3. Non-B DNA conformations, mutagenesis and disease.

4. Complete disproportionation of duplex poly(dT)poly(dA) into triplex poly(dT)poly(dA)*poly(dT) and poly(dA) by coralyne.

Review 5. Replication Through Repetitive DNA Elements and Their Role in Human Diseases.

6. Coralyne has a preference for intercalation between TA.T triples in intramolecular DNA triple helices.

7. Naturally occurring H-DNA-forming sequences are mutagenic in mammalian cells.

8. A triplex-forming sequence from the human c-MYC promoter interferes with DNA transcription.

9. DNA structure-induced genomic instability in vivo.

10. Coralyne binds tightly to both T.A.T- and C.G.C(+)-containing DNA triplexes.

1. Anomeric DNA Strand Displacement with α-D Oligonucleotides as Invaders and Ethidium Bromide as Fluorescence Sensor for Duplexes with α/β-, β/β- and α/α-D Configuration.