Elizabeth Spry1,2, Craig A Olsson1,2,3, Stephen J C Hearps1,4, Stephanie Aarsman1, John B Carlin3,5,6, Louise M Howard7,8, Margarita Moreno-Betancur3,5, Helena Romaniuk9, Lex W Doyle4,10,11, Stephanie Brown3,12,13, Rohan Borschmann1,6,7,14, Yvette Alway1, Carolyn Coffey1, George C Patton1,3. 1. Murdoch Children's Research Institute, Centre for Adolescent Health, Melbourne, Victoria, Australia. 2. Centre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Deakin University Geelong, Geelong, Victoria, Australia. 3. Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia. 4. Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Victoria, Australia. 5. Clinical Epidemiology & Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Victoria, Australia. 6. The University of Melbourne, Melbourne School of Population and Global Health, Melbourne, Victoria, Australia. 7. Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. 8. South London and Maudsley NHS Foundation Trust, London, UK. 9. Biostatistics Unit, Faculty of Health, Deakin University Geelong, Melbourne, Victoria, Australia. 10. Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Victoria, Australia. 11. Research Office, The Royal Women's Hospital, Melbourne, Victoria, Australia. 12. Intergenerational Health, Murdoch Children's Research Institute, Melbourne, Victoria, Australia. 13. Department of General Practice, The University of Melbourne, Melbourne, Victoria, Australia. 14. The University of Melbourne, Melbourne School of Psychological Sciences, Melbourne, Victoria, Australia.
Abstract
BACKGROUND: There is increasing evidence that parental determinants of offspring early life development begin well before pregnancy. OBJECTIVES: We established the Victorian Intergenerational Health Cohort Study (VIHCS) to examine the contributions of parental mental health, substance use, and socio-economic characteristics before pregnancy to child emotional, physical, social, and cognitive development. POPULATION: Men and women were recruited from the Victorian Adolescent Health Cohort (VAHCS), an existing cohort study beginning in 1992 that assessed a representative sample of 1943 secondary school students in Victoria, Australia, repeatedly from adolescence (wave 1, mean age 14 years) to adulthood (wave 10, mean age 35 years). METHODS: Victorian Adolescent Health Cohort participants with children born between 2006 and 2013 were recruited to VIHCS and invited to participate during trimester three, at 2 months postpartum, and 1 year postpartum. Parental mental health, substance use and socio-economic characteristics were assessed repeatedly throughout; infant characteristics were assessed postnatally and in infancy. Data will be supplemented by linkage to routine datasets. A further follow-up is underway as children reach 8 years of age. PRELIMINARY RESULTS: Of the 1307 infants born to VAHCS participants between 2006 and 2013, 1030 were recruited to VIHCS. At VIHCS study entry, 18% of recruited parents had preconception common mental disorder in adolescence and young adulthood, 18% smoked daily in adolescence and young adulthood, and 6% had not completed high school. Half of VIHCS infants were female (48%), 4% were from multiple births, and 7% were preterm (<37 weeks' gestation). CONCLUSIONS: Victorian Intergenerational Health Cohort Study is a prospective cohort of 1030 children with up to nine waves of preconception parental data and three waves of perinatal parental and infant data. These will allow examination of continuities of parental health and health risks from the decades before pregnancy to offspring childhood, and the contributions of exposures before pregnancy to offspring outcomes in childhood.
BACKGROUND: There is increasing evidence that parental determinants of offspring early life development begin well before pregnancy. OBJECTIVES: We established the Victorian Intergenerational Health Cohort Study (VIHCS) to examine the contributions of parental mental health, substance use, and socio-economic characteristics before pregnancy to child emotional, physical, social, and cognitive development. POPULATION: Men and women were recruited from the Victorian Adolescent Health Cohort (VAHCS), an existing cohort study beginning in 1992 that assessed a representative sample of 1943 secondary school students in Victoria, Australia, repeatedly from adolescence (wave 1, mean age 14 years) to adulthood (wave 10, mean age 35 years). METHODS: Victorian Adolescent Health Cohort participants with children born between 2006 and 2013 were recruited to VIHCS and invited to participate during trimester three, at 2 months postpartum, and 1 year postpartum. Parental mental health, substance use and socio-economic characteristics were assessed repeatedly throughout; infant characteristics were assessed postnatally and in infancy. Data will be supplemented by linkage to routine datasets. A further follow-up is underway as children reach 8 years of age. PRELIMINARY RESULTS: Of the 1307 infants born to VAHCS participants between 2006 and 2013, 1030 were recruited to VIHCS. At VIHCS study entry, 18% of recruited parents had preconception common mental disorder in adolescence and young adulthood, 18% smoked daily in adolescence and young adulthood, and 6% had not completed high school. Half of VIHCS infants were female (48%), 4% were from multiple births, and 7% were preterm (<37 weeks' gestation). CONCLUSIONS: Victorian Intergenerational Health Cohort Study is a prospective cohort of 1030 children with up to nine waves of preconception parental data and three waves of perinatal parental and infant data. These will allow examination of continuities of parental health and health risks from the decades before pregnancy to offspring childhood, and the contributions of exposures before pregnancy to offspring outcomes in childhood.
Authors: Craig A Olsson; Elizabeth A Spry; Yvette Alway; Margarita Moreno-Betancur; George Youssef; Christopher Greenwood; Primrose Letcher; Jacqui A Macdonald; Jennifer McIntosh; Delyse Hutchinson; George C Patton Journal: Arch Womens Ment Health Date: 2020-10-27 Impact factor: 3.633
Authors: Elizabeth A Spry; Margarita Moreno-Betancur; Melissa Middleton; Louise M Howard; Stephanie J Brown; Emma Molyneaux; Christopher J Greenwood; Primrose Letcher; Jacqui A Macdonald; Kimberly C Thomson; Ebony J Biden; Craig A Olsson; George C Patton Journal: Philos Trans R Soc Lond B Biol Sci Date: 2021-05-03 Impact factor: 6.671
Authors: Meredith O'Connor; Margarita Moreno-Betancur; Sharon Goldfeld; Melissa Wake; George Patton; Terence Dwyer; Mimi L K Tang; Richard Saffery; Jeffrey M Craig; Jane Loke; David Burgner; Craig A Olsson Journal: Int J Epidemiol Date: 2022-10-13 Impact factor: 9.685
Authors: Elizabeth A Spry; Claire A Wilson; Melissa Middleton; Margarita Moreno-Betancur; Lex W Doyle; Louise M Howard; Anthony J Hannan; Mary E Wlodek; Jeanie Ly Cheong; Lindsey A Hines; Carolyn Coffey; Stephanie Brown; Craig A Olsson; George C Patton Journal: EClinicalMedicine Date: 2020-10-12