| Literature DB >> 31959516 |
Benjamin C Reeves1, Jason K Karimy1, Adam J Kundishora1, Humberto Mestre2, H Mert Cerci3, Charles Matouk1, Seth L Alper4, Iben Lundgaard5, Maiken Nedergaard6, Kristopher T Kahle7.
Abstract
Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and Alzheimer's disease (AD) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-β (Aβ) plaques, perivascular reactive astrogliosis, and mislocalization of astrocyte aquaporin-4 (AQP4). The glia-lymphatic (glymphatic) system facilitates brain fluid clearance and waste removal during sleep via glia-supported perivascular channels. Human studies have implicated impaired glymphatic function in both AD and iNPH. Continued investigation into the role of glymphatic system biology in AD and iNPH models could lead to new strategies to improve brain health by restoring homeostatic brain metabolism and CSF dynamics.Entities:
Keywords: Alzheimer’s disease; aging; dementia; glial-lymphatic; glymphatic; hydrocephalus; idiopathic normal pressure hydrocephalus
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Year: 2020 PMID： 31959516 PMCID： PMC7489754 DOI： 10.1016/j.molmed.2019.11.008
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951