Elizabeth Carolina Jiménez1,2, Claudia Avella-Garcia3, James Kustow4, Sally Cubbin5, Montse Corrales6,7,8,9, Vanessa Richarte6,7,8,9, Flavia Lorena Esposito10, Imanol Morata10,11,12, Alexandre Perera11, Paloma Varela7,13, Jose Cañete13, Stephen V Faraone14, Hans Supèr1,10,12,15, Josep Antoni Ramos-Quiroga6,7,8,9. 1. University of Barcelona, Spain. 2. Universidad de Guadalajara, México. 3. Hospital Sagrat Cor, Barcelona, Spain. 4. Manor Hospital, Oxford, UK. 5. Cardinal Clinic, Windsor, UK. 6. Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain. 7. Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Spain. 8. Biomedical Network Research Centre on Mental Health, Barcelona, Spain. 9. Vall d'Hebron Research Institute, Barcelona, Spain. 10. Braingaze SL, Mataró, Spain. 11. Universitat Politècnica de Catalunya, Barcelona, Spain. 12. Pediatric Research Institute Hospital Sant Joan de Déu, Barcelona, Spain. 13. Consorci Sanitari del Maresme, Mataró, Spain. 14. SUNY Upstate Medical University, Syracuse, NY, USA. 15. Catalan Institution for Research and Advanced Studies, Barcelona, Spain.
Abstract
Objective: ADHD patients show poor oculomotor control and recent studies show that attention-related eye vergence is weak in ADHD children. We aimed to assess vergence as a potential diagnostic biomarker for ADHD in adults. Method: We assessed the modulation in the angle of vergence while performing an attention task (N = 144), comparing the results for adults previously diagnosed with ADHD (N = 108) with age-matched clinical controls (N = 36). Results: Significant differences in eye vergence response modulation between clinical controls and ADHD patients were documented. Diagnostic test accuracy was 79%. Conclusion: In combination with an attention task, eye vergence responses could be used as an objective marker to support the clinical diagnosis of adult ADHD.
Objective: ADHDpatients show poor oculomotor control and recent studies show that attention-related eye vergence is weak in ADHDchildren. We aimed to assess vergence as a potential diagnostic biomarker for ADHD in adults. Method: We assessed the modulation in the angle of vergence while performing an attention task (N = 144), comparing the results for adults previously diagnosed with ADHD (N = 108) with age-matched clinical controls (N = 36). Results: Significant differences in eye vergence response modulation between clinical controls and ADHDpatients were documented. Diagnostic test accuracy was 79%. Conclusion: In combination with an attention task, eye vergence responses could be used as an objective marker to support the clinical diagnosis of adult ADHD.