Timothy P Siejka1,2, Velandai K Srikanth1,3, Ruth E Hubbard4, Chris Moran3, Richard Beare3,5, Amanda Wood6,7, Thanh Phan3, Saliu Balogun1, Michele L Callisaya1,3. 1. Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. 2. Alfred Health, Melbourne, Victoria, Australia. 3. Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Victoria, Australia. 4. Faculty of Medicine, University of Queensland, Brisbane, Australia. 5. Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Victoria, Australia. 6. School of Life and Health Sciences & Aston Brain Centre, Aston University, Birmingham, UK. 7. School of Psychology, Faculty of Health, Melbourne Burwood Campus, Deakin University, Geelong, Victoria, Australia.
Abstract
BACKGROUND: The contribution of cerebral small vessel disease (cSVD) to the pathogenesis of frailty remains uncertain. We aimed to examine the associations between cSVD with progression of frailty in a population-based study of older people. METHODS: People aged between 60 and 85 years were randomly selected form the electoral roll to participate in the Tasmanian Study of Cognition and Gait. Participants underwent self-reported questionnaires, objective gait, cognitive and sensorimotor testing over three phases ranging between 2005 and 2012. These data were used to calculate a 41-item frailty index (FI) at three time points. Baseline brain magnetic resonance imaging was performed on all participants to measure cSVD. Generalized mixed models were used to examine associations between baseline cSVD and progression of frailty, adjusted for confounders of age, sex, level of education, and total intracranial volume. RESULTS: At baseline (n = 388) mean age was 72 years (SD = 7.0), 44% were female, and the median FI score was 0.20 (interquartile range [IQR] 0.12, 0.27). In fully adjusted models higher burden of baseline white matter hyperintensity (WMH) was associated with frailty progression over 4.4 years (β = 0.03, 95% CI: 0.01, 0.05; p = .004) independent of other SVD markers. Neither baseline infarcts (p = .23), nor microbleeds at baseline (p = .65) were associated with progression of frailty. CONCLUSIONS: We provide evidence for an association between baseline WMHs and progression of frailty. Our findings add to a growing body of literature suggesting WMH is a marker for frailty.
BACKGROUND: The contribution of cerebral small vessel disease (cSVD) to the pathogenesis of frailty remains uncertain. We aimed to examine the associations between cSVD with progression of frailty in a population-based study of older people. METHODS:People aged between 60 and 85 years were randomly selected form the electoral roll to participate in the Tasmanian Study of Cognition and Gait. Participants underwent self-reported questionnaires, objective gait, cognitive and sensorimotor testing over three phases ranging between 2005 and 2012. These data were used to calculate a 41-item frailty index (FI) at three time points. Baseline brain magnetic resonance imaging was performed on all participants to measure cSVD. Generalized mixed models were used to examine associations between baseline cSVD and progression of frailty, adjusted for confounders of age, sex, level of education, and total intracranial volume. RESULTS: At baseline (n = 388) mean age was 72 years (SD = 7.0), 44% were female, and the median FI score was 0.20 (interquartile range [IQR] 0.12, 0.27). In fully adjusted models higher burden of baseline white matter hyperintensity (WMH) was associated with frailty progression over 4.4 years (β = 0.03, 95% CI: 0.01, 0.05; p = .004) independent of other SVD markers. Neither baseline infarcts (p = .23), nor microbleeds at baseline (p = .65) were associated with progression of frailty. CONCLUSIONS: We provide evidence for an association between baseline WMHs and progression of frailty. Our findings add to a growing body of literature suggesting WMH is a marker for frailty.
Authors: Timothy P Siejka; Velandai K Srikanth; Ruth E Hubbard; Chris Moran; Richard Beare; Amanda G Wood; Taya A Collyer; Siddhanth Gujjari; Thanh G Phan; Michele L Callisaya Journal: J Gerontol A Biol Sci Med Sci Date: 2022-09-01 Impact factor: 6.591
Authors: Nicholas R Evans; Oliver M Todd; Jatinder S Minhas; Patricia Fearon; George W Harston; Jonathan Mant; Gillian Mead; Jonathan Hewitt; Terence J Quinn; Elizabeth A Warburton Journal: Int J Stroke Date: 2021-08-04 Impact factor: 5.266