Literature DB >> 31955542

[Research progress on the effects of plateau hypoxia on blood-brain barrier structure and drug permeability].

Yidan Ding1,2, Wenbin Li1, Rong Wang1,2, Jianchun Zhang3.   

Abstract

Drugs for the treatment of central nervous system diseases need to enter the brain tissue through the blood-brain barrier to function. In high altitude hypoxic environment, there are changes in tight junction proteins of blood-brain barrier tissue structure, transporters in astrocytes and endothelial cells and ATP in endothelial cells; at the same time the permeability of the blood-brain barrier is increased. These changes are an important reference for rational drug use in patients with central nervous system disease in the plateau region. This article reviews the research progress on the effects of plateau hypoxia on the structure of the blood-brain barrier and related drug permeability.

Entities:  

Mesh：

Year:  2019        PMID： 31955542      PMCID： PMC8800771          DOI： 10.3785/j.issn.1008-9292.2019.12.12

Source DB:  PubMed          Journal:  Zhejiang Da Xue Xue Bao Yi Xue Ban        ISSN： 1008-9292


  29 in total

Review 1.  Effects of High Altitude Exposure on Physiology and Pharmacokinetics.

Authors:  Lu Hui; Wang Rong; Jia Zheng-Ping; Xiong Juan; Xie Hua
Journal:  Curr Drug Metab       Date:  2016       Impact factor: 3.731

Review 2.  From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery.

Authors:  William A Banks
Journal:  Nat Rev Drug Discov       Date:  2016-01-22       Impact factor: 84.694

3.  Drug delivery: New targets for drug delivery across the BBB.

Authors:  Katie Kingwell
Journal:  Nat Rev Drug Discov       Date:  2016-01-29       Impact factor: 84.694

Review 4.  Acute high-altitude sickness.

Authors:  Andrew M Luks; Erik R Swenson; Peter Bärtsch
Journal:  Eur Respir Rev       Date:  2017-01-31

Review 5.  Development of the calcium plateau following status epilepticus: role of calcium in epileptogenesis.

Authors:  Nisha Nagarkatti; Laxmikant S Deshpande; Robert J DeLorenzo
Journal:  Expert Rev Neurother       Date:  2009-06       Impact factor: 4.618

Review 6.  Cell-specific blood-brain barrier regulation in health and disease: a focus on hypoxia.

Authors:  S Engelhardt; S Patkar; O O Ogunshola
Journal:  Br J Pharmacol       Date:  2014-03       Impact factor: 8.739

Review 7.  Blood brain barrier in hypoxic-ischemic conditions.

Authors:  C Kaur; E A Ling
Journal:  Curr Neurovasc Res       Date:  2008-02       Impact factor: 1.990

Review 8.  Physiology and pathophysiology of the blood-brain barrier: P-glycoprotein and occludin trafficking as therapeutic targets to optimize central nervous system drug delivery.

Authors:  Gwen McCaffrey; Thomas P Davis
Journal:  J Investig Med       Date:  2012-12       Impact factor: 2.895

Review 9.  Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological.

Authors:  Damian Miles Bailey; Peter Bärtsch; Michael Knauth; Ralf W Baumgartner
Journal:  Cell Mol Life Sci       Date:  2009-09-10       Impact factor: 9.261

Review 10.  P-glycoprotein Inhibition for Optimal Drug Delivery.

Authors:  Md Lutful Amin
Journal:  Drug Target Insights       Date:  2013-08-19
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