Literature DB >> 31955056

Adherence to neuroleptic treatment in psychiatric practices: A retrospective study of 55 practices with more than 5000 bipolar and schizophrenic patients in Germany.

Jens Bohlken1, Marcel Konrad2, Karel Kostev3.   

Abstract

BACKGROUND: The aim of this study was to investigate the effect that treating physicians have on the compliance of their psychiatric (schizophrenia (SP) and bipolar disorder (BP)) patients.
METHODS: This retrospective study was based on data from the Disease Analyzer database (IQVIA). It included 2870 SP and 2327 BD patients who had received at least two neuroleptic prescriptions from 55 psychiatric practices between January 2016 and December 2018. The average proportion of days covered (PDC) per patient was calculated. Patients were considered adherent if their PDC was greater than or equal to 80%. Practice adherence was considered high if at least 70% of patients in the practice of interest were adherent.
RESULTS: The mean PDC was 59.8% (SD: 13.9%) in SP and 65.0% (SD: 11.5%) in BD patients. The share of patients with an optimal PDC value (≥80%) differed considerably between practices (between 28% and 92% for SP and between 33% and 92% for BP). The prevalence of practices with high adherence was lower for schizophrenia than for bipolar disorder (21.9% versus 45.5%).
CONCLUSION: Psychiatrists play an important role in the compliance of SP and BP patients treated with neuroleptics.
Copyright © 2020 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Adherence; Antipsychotic drugs; Bipolar disorder; Neuropsychiatric practices; Real-world data; Schizophrenia

Year:  2020        PMID: 31955056     DOI: 10.1016/j.psychres.2020.112758

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN: 0165-1781            Impact factor:   3.222


  2 in total

1.  Real-World Treatment Patterns and Adherence to Oral Medication Among Patients with Bipolar Disorders: A Retrospective, Observational Study Using a Healthcare Claims Database.

Authors:  Takeshi Inoue; Hiromi Sano; Yoshitsugu Kojima; Sakiko Yamada; Osamu Shirakawa
Journal:  Neuropsychiatr Dis Treat       Date:  2021-03-18       Impact factor: 2.570

2.  Development, validation, and application of a quantitative volumetric absorptive microsampling-based method in finger prick blood by means of LC-HRMS/MS applicable for adherence monitoring of antipsychotics.

Authors:  Cathy M Jacobs; Lea Wagmann; Markus R Meyer
Journal:  Anal Bioanal Chem       Date:  2021-01-30       Impact factor: 4.142

  2 in total

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