Young Min Park1, Jeonggeun Moon2, In Cheol Hwang3, Hyunsun Lim4, Bokeum Cho5. 1. Department of Family Medicine, National Health Insurance Service Ilsan Hospital, Goyang, South Korea. 2. Cardiology Division, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea. 3. Department of Family Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea. Electronic address: spfe0211@gmail.com. 4. Department of Policy Research Affairs, National Health Insurance Service Ilsan Hospital, Goyang, South Korea. 5. Division of Humanities Arts and Social Sciences, Underwood International College of Yonsei University, Seoul, South Korea.
Abstract
BACKGROUND: Although increased height is associated with a risk of atrial fibrillation (AF), the mechanism is not well understood. We aimed to explore whether this association varies with metabolic conditions. METHODS AND RESULTS: We used the database from the 14-year Korea National Health Insurance Service-National Sample Cohort. The data of 368,206 adults older than 20 years who received a health check-up were analyzed to explore the association of height and AF risk. Cox proportional hazards regression models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of height with the risk of AF. During the median follow up duration of 8.46 years, 2641 (0.72%) patients were diagnosed with AF at 3,070,724 person-years. Overall, greater height was significantly associated with AF risk (HR per 5 cm, 1.22; 95% CI, 1.03-1.05). The association did not vary with age, sex, obesity, hypertension, and diabetes. CONCLUSION: Metabolic conditions do not affect the higher risk of AF in tall people.
BACKGROUND: Although increased height is associated with a risk of atrial fibrillation (AF), the mechanism is not well understood. We aimed to explore whether this association varies with metabolic conditions. METHODS AND RESULTS: We used the database from the 14-year Korea National Health Insurance Service-National Sample Cohort. The data of 368,206 adults older than 20 years who received a health check-up were analyzed to explore the association of height and AF risk. Cox proportional hazards regression models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of height with the risk of AF. During the median follow up duration of 8.46 years, 2641 (0.72%) patients were diagnosed with AF at 3,070,724 person-years. Overall, greater height was significantly associated with AF risk (HR per 5 cm, 1.22; 95% CI, 1.03-1.05). The association did not vary with age, sex, obesity, hypertension, and diabetes. CONCLUSION: Metabolic conditions do not affect the higher risk of AF in tall people.
Authors: Mingjian Shi; Ali M Manouchehri; Christian M Shaffer; Nataraja Sarma Vaitinadin; Jacklyn N Hellwege; Joe-Elie Salem; Lea K Davis; Jill H Simmons; Dan M Roden; M Benjamin Shoemaker; Jane F Ferguson; Jonathan D Mosley Journal: J Clin Endocrinol Metab Date: 2021-06-16 Impact factor: 5.958