Mohamed M Soliman1, Allison Aguado1, Charles Sutton1, Meera Hameed2, Sinchun Hwang3, John H Healey4, Majid Maybody5. 1. Department of Radiology, Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2. Department of Pathology, Surgical Pathology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 3. Department of Radiology, Body Imaging Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 4. Department of Surgery, Orthopaedic Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 5. Department of Radiology, Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: maybodym@mskcc.org.
Abstract
PURPOSE: To examine the diagnostic yield of intraprocedural percutaneous biopsy performed at the time of radiofrequency ablation of suspected Osteoid Osteoma (OO) and identify technical and nidus-specific factors associated with diagnostic adequacy. MATERIALS AND METHODS: Following IRB approval, a total of 42 patients (male: 28, female: 14; mean age: 29 years) who underwent intraprocedural biopsy immediately prior to RFA between June 2010 and June 2017 were retrospectively identified. The nidi were located in various locations. The nidi had a mean size of 6.3 mm (range: 3-11 mm, Standard deviation (SD): 2.26). Core biopsies were performed by one of 15 operators. Biopsies were performed with two needle types ranging from 11-G to 15-G with a mean number of samples of 1.8 (range: 1-5, SD: 1.01). Electronic records and imaging were reviewed for demographics, nidus characteristics, biopsy details and diagnostic yield. Multivariate logistic regression of nidus-specific and biopsy-specific factors was performed. RESULTS: A total of 22/42 (52.3%) of the biopsies were adequate for histological diagnosis of OO. For the two experienced operators, the diagnostic yield was 67% (6/9) and 80% (8/10). Biopsy adequacy was significantly correlated with presence of an osteoid matrix (p = 0.03), obtaining >1 core sample (p = 0.03), the needle track passing through the nidus (p = 0.0003) and thinner (2.5 mm) intraprocedural CT slices (p = 0.03). On multivariate analysis, use of thinner intraprocedural CT slices was found to be associated with adequate biopsy (p = 0.02). CONCLUSION: Intraprocedural percutaneous biopsy samples of nidi highly-suspected to be OO at the time of RFA were diagnostic in 52% of patients. Multivariate analysis shows thinner intraprocedural CT slices to be a significantly associated with biopsy adequacy.
PURPOSE: To examine the diagnostic yield of intraprocedural percutaneous biopsy performed at the time of radiofrequency ablation of suspected Osteoid Osteoma (OO) and identify technical and nidus-specific factors associated with diagnostic adequacy. MATERIALS AND METHODS: Following IRB approval, a total of 42 patients (male: 28, female: 14; mean age: 29 years) who underwent intraprocedural biopsy immediately prior to RFA between June 2010 and June 2017 were retrospectively identified. The nidi were located in various locations. The nidi had a mean size of 6.3 mm (range: 3-11 mm, Standard deviation (SD): 2.26). Core biopsies were performed by one of 15 operators. Biopsies were performed with two needle types ranging from 11-G to 15-G with a mean number of samples of 1.8 (range: 1-5, SD: 1.01). Electronic records and imaging were reviewed for demographics, nidus characteristics, biopsy details and diagnostic yield. Multivariate logistic regression of nidus-specific and biopsy-specific factors was performed. RESULTS: A total of 22/42 (52.3%) of the biopsies were adequate for histological diagnosis of OO. For the two experienced operators, the diagnostic yield was 67% (6/9) and 80% (8/10). Biopsy adequacy was significantly correlated with presence of an osteoid matrix (p = 0.03), obtaining >1 core sample (p = 0.03), the needle track passing through the nidus (p = 0.0003) and thinner (2.5 mm) intraprocedural CT slices (p = 0.03). On multivariate analysis, use of thinner intraprocedural CT slices was found to be associated with adequate biopsy (p = 0.02). CONCLUSION: Intraprocedural percutaneous biopsy samples of nidi highly-suspected to be OO at the time of RFA were diagnostic in 52% of patients. Multivariate analysis shows thinner intraprocedural CT slices to be a significantly associated with biopsy adequacy.
Authors: N Sans; D Galy-Fourcade; J Assoun; T Jarlaud; H Chiavassa; P Bonnevialle; N Railhac; J Giron; H Morera-Maupomé; J J Railhac Journal: Radiology Date: 1999-09 Impact factor: 11.105
Authors: Majid Maybody; Mohamed M Soliman; Sinchun Hwang; Adrian Gonzalez-Aguirre; Ernesto G Santos Martin; Elena Kaye; Meier Hsu; Chaya Moskowitz; John H Healey; Nicola Fabbri Journal: SN Compr Clin Med Date: 2020-09-14