Ülkü Türk Börü1, Cem Bölük1,2, Mustafa Taşdemir3, Tuğçe Gezer4, Vedat Ataman Serim5. 1. Department of Neurology, Afyonkarahisar University of Health Sciences, Afyon, Turkey. 2. Department of Neurology and Clinical Neurophysiology, Cerrahpaşa Faculty of Medicine, Istanbul University Cerrahpaşa, Istanbul, Turkey. 3. Department of Public Health, Istanbul Medeniyet University, Istanbul, Turkey. 4. Department of Neurology, University of Health Sciences Dr. Lütfi Kırdar Kartal Training and Research Hospital, Istanbul, Turkey. 5. Department of Neurology, Gümüşhane State Hospital, Gümüşhane, Turkey.
Abstract
OBJECTIVE: Studies focusing attention on the effects of environmental pollution on the etiology of multiple sclerosis (MS) are on the increase. The aim of this study was to determine MS prevalence in a city home to an iron and steel factory which causes air pollution. METHODS: The study was designed as a cross-sectional, population-based, descriptive epidemiologic study. Ereğli city, which has an iron and steel factory and proven air pollution, was screened. Additionally, Devrek city, which is a rural and clean city, located 40 km away from Ereğli was assigned and results were compared. A validated questionnaire was used for screening. McDonald 2010 criteria were used to diagnose cases. RESULTS: 32 261 people were screened in Ereğli, and 21 963 people were screened in Devrek. In total, 41 patients were diagnosed with clinical definite MS. Crude prevalence was found to be 96.1/100 000 in Ereğli and 45.5/100 000 in Devrek. The mean age of patients was 39.8, and the female/male ratio was 1.9. CONCLUSION: The results of this study indicate a more than double MS prevalence rate in the area home to an iron and steel factory when compared to the rural city. This supports the hypothesis that air pollution may be a possible etiological factor in MS.
OBJECTIVE: Studies focusing attention on the effects of environmental pollution on the etiology of multiple sclerosis (MS) are on the increase. The aim of this study was to determine MS prevalence in a city home to an iron and steel factory which causes air pollution. METHODS: The study was designed as a cross-sectional, population-based, descriptive epidemiologic study. Ereğli city, which has an iron and steel factory and proven air pollution, was screened. Additionally, Devrek city, which is a rural and clean city, located 40 km away from Ereğli was assigned and results were compared. A validated questionnaire was used for screening. McDonald 2010 criteria were used to diagnose cases. RESULTS: 32 261 people were screened in Ereğli, and 21 963 people were screened in Devrek. In total, 41 patients were diagnosed with clinical definite MS. Crude prevalence was found to be 96.1/100 000 in Ereğli and 45.5/100 000 in Devrek. The mean age of patients was 39.8, and the female/male ratio was 1.9. CONCLUSION: The results of this study indicate a more than double MS prevalence rate in the area home to an iron and steel factory when compared to the rural city. This supports the hypothesis that air pollution may be a possible etiological factor in MS.