Elien Van der Gucht1,2, Lore Dams3,4, Mira Meeus4, Nele Devoogdt3,5, Annemarie Beintema6,7, Frauke Penen3,4, Wouter Hoelen6, Tessa De Vrieze3,4, An De Groef3,4. 1. Department of Rehabilitation Sciences, KU Leuven, University of Leuven, ON4 Herestraat 49 - box 1510, 3000, Leuven, Belgium. elien.vandergucht@kuleuven.be. 2. Department of Rehabilitation Sciences and Physiotherapy, MOVANT, University of Antwerp, Antwerp, Belgium. elien.vandergucht@kuleuven.be. 3. Department of Rehabilitation Sciences, KU Leuven, University of Leuven, ON4 Herestraat 49 - box 1510, 3000, Leuven, Belgium. 4. Department of Rehabilitation Sciences and Physiotherapy, MOVANT, University of Antwerp, Antwerp, Belgium. 5. Department of Vascular Surgery and Department of Physical Medicine and Rehabilitation, Center for Lymphoedema, UZ Leuven, University Hospitals Leuven, Leuven, Belgium. 6. The Berekuyl Academy, Hierden, the Netherlands. 7. Cancer Care Center, Amsterdam, the Netherlands.
Abstract
PURPOSE: Pain is one of the most prevalent problems reported by breast cancer survivors. As this long-lasting complication can result in disabilities on all different domains of functioning, we aimed to clarify the contribution of different factors (pain-related factors, psychosocial factors, and fatigue) to pain-related disability in female breast cancer survivors. METHODS: Seventy women who had completed their primary breast cancer treatment were included in this cross-sectional study. The following outcome measures were evaluated as independent variables for their contribution to pain-related disability (measured by the Pain Disability Index, with a maximum score of 70): pain intensity, self-reported symptoms of central sensitization, fatigue, illness beliefs, pain catastrophizing, and kinesiophobia. At first, bi- and multivariable regression methods were conducted. Secondly, a stepwise regression analysis was performed to determine the explained variance of the PDI. RESULTS: Mean score on the PDI was 16 at 4.5 years post-surgery. Multivariable regression analysis revealed higher levels of kinesiophobia as the main contributor to pain-related disability. Ultimately, stepwise regression showed that up to 40% of variance in pain-related disability could be explained by kinesiophobia, negative perceptions related to illness consequences, and pain catastrophizing. CONCLUSION: This study shows that breast cancer survivors portray moderate self-reported pain-related disability. Kinesiophobia emerged as the main contributor to pain-related disability at this time point, which could shine a light on the improvement of treatment modalities for pain management in this population.
PURPOSE:Pain is one of the most prevalent problems reported by breast cancer survivors. As this long-lasting complication can result in disabilities on all different domains of functioning, we aimed to clarify the contribution of different factors (pain-related factors, psychosocial factors, and fatigue) to pain-related disability in female breast cancer survivors. METHODS: Seventy women who had completed their primary breast cancer treatment were included in this cross-sectional study. The following outcome measures were evaluated as independent variables for their contribution to pain-related disability (measured by the Pain Disability Index, with a maximum score of 70): pain intensity, self-reported symptoms of central sensitization, fatigue, illness beliefs, pain catastrophizing, and kinesiophobia. At first, bi- and multivariable regression methods were conducted. Secondly, a stepwise regression analysis was performed to determine the explained variance of the PDI. RESULTS: Mean score on the PDI was 16 at 4.5 years post-surgery. Multivariable regression analysis revealed higher levels of kinesiophobia as the main contributor to pain-related disability. Ultimately, stepwise regression showed that up to 40% of variance in pain-related disability could be explained by kinesiophobia, negative perceptions related to illness consequences, and pain catastrophizing. CONCLUSION: This study shows that breast cancer survivors portray moderate self-reported pain-related disability. Kinesiophobia emerged as the main contributor to pain-related disability at this time point, which could shine a light on the improvement of treatment modalities for pain management in this population.
Entities:
Keywords:
Breast cancer; Pain; Pain disability index; Pain-related disability
Authors: Muhammad Umar Jawad; Brad H Pollock; Barton L Wise; Lauren N Zeitlinger; Edmond F O' Donnell; Janai R Carr-Ascher; Amy Cizik; Betty Ferrell; Steven W Thorpe; R Lor Randall Journal: J Surg Oncol Date: 2021-12-10 Impact factor: 2.885